| From head to toe: conservation of molecular signals regulating limb and craniofacial morphogenesis. | |
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MedLine Citation:
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PMID: 10199970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent evidence indicates that many molecules involved in generating and patterning the limbs also play a role during craniofacial morphogenesis. On the surface, this is an unexpected finding given that these regions of the body have separate evolutionary origins, are composed of different embryonic tissues, and are quite dissimilar in their anatomy. Results from several experiments involving Sonic hedgehog and retinoic acid point to a remarkable conservation of the signaling pathways mediated by these morphogens across multiple organ systems. Moreover, mutants such as the extra-toes and doublefoot mouse, and the talpid chicken also provide insights on common developmental processes that underlie the formation of the limbs and face. The identification of highly conserved aspects of morphogenesis is important for understanding fundamental mechanisms of development, as well as for revealing the common denominator of countless birth defects and providing new strategies for their prevention and cure. |
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Authors:
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R A Schneider; D Hu; J A Helms |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cell and tissue research Volume: 296 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 1999 Apr |
Date Detail:
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Created Date: 1999-05-17 Completed Date: 1999-05-17 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: GERMANY |
Other Details:
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Languages: eng Pagination: 103-9 Citation Subset: IM |
Affiliation:
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Department of Orthopaedic Surgery, School of Medicine, University of California at San Francisco, 533 Parnassus Ave. U-453, San Francisco, CA 94143-0514, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning Embryonic and Fetal Development Evolution Extremities / embryology* Face / embryology* Limb Deformities, Congenital / physiopathology* Mice Morphogenesis Signal Transduction Skull / embryology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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