Document Detail

From the experimental myocardial infarction to the clinical acute myocardial infarction: limitations of thrombolytic therapy.
MedLine Citation:
PMID:  7591319     Owner:  NLM     Status:  MEDLINE    
Early administration of thrombolytic agents in acute myocardial infarction lowers mortality and preserves left ventricular function. Currently, only one third of infarct patients receive this treatment, the vast majority being excluded because of restrictive criteria and delayed hospital admission. When correctly administered, thrombolytic therapy achieves reperfusion in 50-85% of occluded vessels. Five to 15% of these initially recanalized vessels eventually reocclude. Possible mechanisms of failure of thrombolytic therapy to induce stable coronary reperfusion include thrombus formation during thrombolysis, platelet activation by thrombolysis, fibrin deposition during thrombolysis, and resistance to thrombolysis. Bleeding complications including intracranial haemorrhage remain a major complication. New therapeutic regimens, new thrombolytic agents and more effective anti-thrombotic drugs, together with intervention strategies that anticipate the time of treatment, promise a significant increase of the overall benefits obtainable with thrombolysis in acute myocardial infarction.
M Marzilli
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International journal of cardiology     Volume:  49 Suppl     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  S71-5     Citation Subset:  IM    
University of Pisa Medical School, Institute of Clinical Physiology CNR, Pisa, Italy.
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MeSH Terms
Blood Platelets / drug effects
Cerebral Hemorrhage / chemically induced
Emergency Medical Services
Fibrinolytic Agents / pharmacology*,  therapeutic use
Myocardial Infarction / drug therapy*
Thrombolytic Therapy* / adverse effects,  utilization
Thrombosis / physiopathology
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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