Document Detail

From evidence to action? Challenges to policy change and programme delivery for malaria in pregnancy.
MedLine Citation:
PMID:  17251085     Owner:  NLM     Status:  MEDLINE    
This paper discusses the factors that influence whether strategies for preventing and treating malaria in pregnancy are successfully translated into national policy and programme implementation, and identifies key operational research issues. Countries require guidance on how to assess the effectiveness of intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine in the context of increasing sulfadoxine-pyrimethamine resistance. At the same time, data on the safety and efficacy of alternatives to sulfadoxine-pyrimethamine for prevention and treatment are urgently needed. Systematic examination of the cultural and operational constraints to delivery and uptake of IPTp with sulfadoxine-pyrimethamine and use of insecticide-treated nets would provide a rational basis for strategies aimed at improving coverage. Standardised methodology must be used to monitor IPTp coverage and to compare different approaches for scaling-up the delivery of insecticide-treated nets to pregnant women. Adequate budgetary provision for the implementation of policy and for operational research to improve programme delivery should be included in national applications to the Global Fund to Fight AIDS, Tuberculosis and Malaria. The provision of clear policy guidance on malaria in pregnancy and its translation into evidence-based guidelines that are made widely available at a country level are central to improving malaria control in this particularly vulnerable group.
Jane Crawley; Jenny Hill; Juliana Yartey; Magda Robalo; Antoine Serufilira; Antoinette Ba-Nguz; Elaine Roman; Ayo Palmer; Kwame Asamoa; Richard Steketee
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Lancet. Infectious diseases     Volume:  7     ISSN:  1473-3099     ISO Abbreviation:  Lancet Infect Dis     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-25     Completed Date:  2007-03-02     Revised Date:  2014-08-15    
Medline Journal Info:
Nlm Unique ID:  101130150     Medline TA:  Lancet Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-55     Citation Subset:  IM    
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MeSH Terms
Africa South of the Sahara
Antimalarials / administration & dosage,  therapeutic use*
Delivery of Health Care*
Drug Combinations
Health Policy*
Malaria, Falciparum / drug therapy,  parasitology,  prevention & control*
Plasmodium falciparum / drug effects
Pregnancy Complications, Parasitic / drug therapy,  parasitology,  prevention & control*
Prenatal Care / methods,  statistics & numerical data
Pyrimethamine / administration & dosage,  therapeutic use*
Sulfadoxine / administration & dosage,  therapeutic use*
World Health Organization
Reg. No./Substance:
0/Antimalarials; 0/Drug Combinations; 37338-39-9/fanasil, pyrimethamine drug combination; 88463U4SM5/Sulfadoxine; Z3614QOX8W/Pyrimethamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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