| From dynamic to cellular cardiomyoplasty. | |
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MedLine Citation:
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PMID: 12489902 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic Cardiomyoplasty. Latissimus dorsi dynamic cardiomyoplasty has been used in our institution for heart failure patients refractory to medical therapy; 113 cases were operated at Broussais and Pompidou Hospitals and 75 patients by our team abroad, in the scope of an international cooperative program. Cardiomyoplasty has been associated with better results due to technical improvements, the most significant mini-invasive techniques, the latest the use of growth factors to enhance muscle vascularization. Risk factors have been identified, resulting in more precise indications, a lower hospital mortality, and a wider use of this operation. There has been a new tendency to associate cardiomyoplasty with electrophysiological therapies: implantation of ventricular defibrillators and multisite cardiac pacing (for atrioventricular and interventricular resynchronization). Cellular Cardiomyoplasty. Adult myocardium cannot repair after infarction due to the absence of stem cells. Cell transplantation strategies for heart failure have been designed to replace damaged cells with cells that can perform cardiac work. Current possibilities in cell therapy for heart failure is the transplantation into the infarcted myocardium of autologous myoblasts (satellite cells originated from skeletal muscle), fetal cardiomyocytes, autologous heart cells, cells derived from bone marrow stem cells, and smooth muscle cells. Experimental studies demonstrated that cell transplantation into the myocardium was associated with the recovery of myocardial contractility and compliance, as well as the diastolic pressure-strain relationship in animal models (infarctlike myocardial lesions and dilated cardiomyopathy models). Healthy myoblasts and myotubes were observed 2 months after myocardial implantation. Clinical studies are now in progress. |
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Authors:
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Juan C Chachques; Abdel Shafy; Fabricio Duarte; Barbara Cattadori; Nathalie Goussef; Lin Shen; Alain Carpentier |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of cardiac surgery Volume: 17 ISSN: 0886-0440 ISO Abbreviation: J Card Surg Publication Date: 2002 May-Jun |
Date Detail:
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Created Date: 2002-12-19 Completed Date: 2003-04-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8908809 Medline TA: J Card Surg Country: United States |
Other Details:
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Languages: eng Pagination: 194-200 Citation Subset: IM |
Affiliation:
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Department of Cardiac Surgery, Ponpidou Hospital, Paris, France. j.chachques@brs.ap-hop-paris.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Surgical Procedures Cardiomyoplasty / methods* Heart Failure / physiopathology, surgery Heart Transplantation Heart-Assist Devices Humans Myocardial Contraction / physiology Myocardium / cytology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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