Document Detail

From the decidual cell internet: trophoblast-recognizing T cells.
MedLine Citation:
PMID:  9915985     Owner:  NLM     Status:  MEDLINE    
The mammalian fetus has been perceived, paradoxically, as a successful allograft, a successful tumor, and a successful parasite. Success depends on fetal trophoblast cells, which form the interface with the mother. The maternal immune system is involved in the success of pregnancy and in its failure. The discovery that maternal gammadelta T cells may recognize and react to the fetal trophoblast and the definition of a vascular mechanism whereby their Th1 and Th2/3-type cytokines may abort embryos replaces confusion and debate with a new and simple clarity that enables further research.
P Arck; J Dietl; D Clark
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biology of reproduction     Volume:  60     ISSN:  0006-3363     ISO Abbreviation:  Biol. Reprod.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-04-13     Completed Date:  1999-04-13     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
Charité, Campus Virchow Klinikum, Humbolt University, 13353 Berlin, Germany.
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MeSH Terms
Antigens / immunology
Decidua / immunology*
Killer Cells, Natural / immunology
Receptors, Antigen, T-Cell, gamma-delta / analysis,  immunology
T-Lymphocytes / immunology*
Trophoblasts / immunology*
Reg. No./Substance:
0/Antigens; 0/Receptors, Antigen, T-Cell, gamma-delta

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