| From crucial to negligible: Functional CD8(+) T-cell responses and their dependence on CD4(+) T-cell help. | |
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MedLine Citation:
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PMID: 22539281 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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CD8(+) T cells play an important role in controlling pathogenic infections and are therefore key players in the immune response. It has been shown that among other factors CD4(+) T cells can shape the magnitude as well as the quality of primary and/or secondary CD8(+) T-cell responses. However, due to the complexity and the differences among diverse immunization or infection models, the overall requirement, the time points, as well as the specific mechanism(s) of CD4(+) T-cell help may differ substantially. Here, we summarize current knowledge about the differential requirement of CD4(+) T-cell help in promoting primary CD8(+) T-cell responses as well as establishing functional memory CD8(+) T cells in various experimental settings. |
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Authors:
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Melanie Wiesel; Annette Oxenius |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of immunology Volume: 42 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 1080-8 Citation Subset: IM |
Copyright Information:
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© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Institute for Microbiology, ETH Zürich, Zürich, Switzerland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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