Document Detail


From the cradle to the grave: activities of GATA-3 throughout T-cell development and differentiation.
MedLine Citation:
PMID:  20969588     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
GATA family transcription factors play multiple vital roles in hematopoiesis in many cell lineages, and in particular, T cells require GATA-3 for execution of several developmental steps. Transcriptional activation of the Gata3 gene is observed throughout T-cell development and differentiation in a stage-specific fashion. GATA-3 has been described as a master regulator of T-helper 2 (Th2) cell differentiation in mature CD4(+) T cells. During T-cell development in the thymus, its roles in the CD4 versus CD8 lineage choice and at the β-selection checkpoint are the best characterized. In contrast, its importance prior to β-selection has been obscured both by the developmental heterogeneity of double negative (DN) 1 thymocytes and the paucity of early T-lineage progenitors (ETPs), a subpopulation of DN1 cells that contains the most immature thymic progenitors that retain potent T-lineage developmental potential. By examining multiple lines of in vivo evidence procured through the analysis of Gata3 mutant mice, we have recently demonstrated that GATA-3 is additionally required at the earliest stage of thymopoiesis for the development of the ETP population. Here, we review the characterized functions of GATA-3 at each stage of T-cell development and discuss hypothetical molecular pathways that mediate these functions.
Authors:
Tomonori Hosoya; Ivan Maillard; James D Engel
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  238     ISSN:  1600-065X     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-25     Completed Date:  2011-05-10     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  110-25     Citation Subset:  IM    
Copyright Information:
© 2010 John Wiley & Sons A/S.
Affiliation:
Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / immunology
Cell Lineage
GATA3 Transcription Factor / genetics,  immunology*
Gene Expression Regulation, Developmental* / immunology
Humans
Mice
Mice, Mutant Strains
Models, Immunological
T-Lymphocyte Subsets / immunology*
Th2 Cells / immunology*
Thymus Gland / embryology,  growth & development,  immunology*
Grant Support
ID/Acronym/Agency:
R01 GM028896/GM/NIGMS NIH HHS; R01 GM28896/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/GATA3 Transcription Factor
Comments/Corrections

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