| From bench to the clinic: gamma-linolenic acid therapy of human gliomas. | |
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MedLine Citation:
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PMID: 15120717 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malignant gliomas are among the most devastating of cancers and are a major cause of mortality in a young population with a median survival time of 9 months following cytoreductive surgery, radiotherapy and chemotherapy. Recent studies showed that polyunsaturated fatty acids especially gamma-linolenic acid (GLA) have selective tumoricidal action especially against malignant glioma cells both in vitro and in vivo. Limited open label clinical studies showed that intratumoral injection/infusion of GLA is safe and effective against malignant gliomas. In view of this, large-scale, double blind studies are needed to establish the usefulness of GLA in the treatment of malignant brain tumors. |
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Authors:
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Undurti N Das |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Prostaglandins, leukotrienes, and essential fatty acids Volume: 70 ISSN: 0952-3278 ISO Abbreviation: Prostaglandins Leukot. Essent. Fatty Acids Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-05-03 Completed Date: 2005-09-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8802730 Medline TA: Prostaglandins Leukot Essent Fatty Acids Country: Scotland |
Other Details:
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Languages: eng Pagination: 539-52 Citation Subset: IM |
Affiliation:
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UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA. undurti@hotmail.com [corrected] |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antineoplastic Agents
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pharmacology*,
therapeutic use* Clinical Trials as Topic Cytoprotection / drug effects Glioma / drug therapy*, pathology, radiotherapy Humans gamma-Linolenic Acid / pharmacology*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 506-26-3/gamma-Linolenic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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