Document Detail

From bench to the clinic: gamma-linolenic acid therapy of human gliomas.
MedLine Citation:
PMID:  15120717     Owner:  NLM     Status:  MEDLINE    
Malignant gliomas are among the most devastating of cancers and are a major cause of mortality in a young population with a median survival time of 9 months following cytoreductive surgery, radiotherapy and chemotherapy. Recent studies showed that polyunsaturated fatty acids especially gamma-linolenic acid (GLA) have selective tumoricidal action especially against malignant glioma cells both in vitro and in vivo. Limited open label clinical studies showed that intratumoral injection/infusion of GLA is safe and effective against malignant gliomas. In view of this, large-scale, double blind studies are needed to establish the usefulness of GLA in the treatment of malignant brain tumors.
Undurti N Das
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  70     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-03     Completed Date:  2005-09-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  539-52     Citation Subset:  IM    
UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA. [corrected]
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MeSH Terms
Antineoplastic Agents / pharmacology*,  therapeutic use*
Clinical Trials as Topic
Cytoprotection / drug effects
Glioma / drug therapy*,  pathology,  radiotherapy
gamma-Linolenic Acid / pharmacology*,  therapeutic use*
Reg. No./Substance:
0/Antineoplastic Agents; 506-26-3/gamma-Linolenic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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