Document Detail


From bench to clinic and back: skeletal stem cells and impaction bone grafting for regeneration of bone defects.
MedLine Citation:
PMID:  23038218     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tissue engineering offers enormous potential for bone regeneration. Despite extensive in vitro and in vivo work, few strategies translate into clinical practice. This paper describes the combination of skeletal stem cells (SSCs) and impaction bone grafting (IBG) for the treatment of patients with bone defects associated with avascular necrosis of the femoral head. SSCs and milled allograft were impacted into necrotic bone in the femoral heads of four patients. Three patients remained asymptomatic at 22-44 month follow-up, but one patient has required total hip replacement (both hips). This has allowed retrieval of the femoral heads, which were analysed structurally and functionally by μCT, histology and mechanical testing. A central channel of impacted bone was found in the femoral heads, which displayed a mature trabecular micro-architecture. The impacted bone was denser than the surrounding trabecular bone, as strong in compression and with histological micro-architecture comparable to that of trabecular bone. Analysis of the retrieved femoral head samples has demonstrated that this tissue-engineering strategy regenerates bone that is both structurally and functionally analogous to normal trabecular bone. SSCs, together with IBG, have proved an effective treatment for avascular necrosis of the femoral head and offer significant potential for the broader spectrum of bone defects. Copyright © 2012 John Wiley & Sons, Ltd.
Authors:
A Aarvold; J O Smith; E R Tayton; A M H Jones; J I Dawson; S Lanham; A Briscoe; D G Dunlop; R O C Oreffo
Related Documents :
24982128 - Ephrinb2 signaling in osteoblasts promotes bone mineralization by preventing apoptosis.
23225778 - A uni-cortical femoral defect model in the rat: evaluation using injectable hyaluronan ...
24014458 - Panostotic expansile bone disease with massive jaw tumor formation and a novel mutation...
23018358 - Chondrosarcoma from the sternum: reconstruction with titanium mesh and a transverse rec...
10471858 - Benefits of routine maxillectomy and orbital reconstruction with the rectus abdominis f...
22879798 - Role of teriparatide in accelerating metatarsal stress fracture healing: a case series ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-5
Journal Detail:
Title:  Journal of tissue engineering and regenerative medicine     Volume:  -     ISSN:  1932-7005     ISO Abbreviation:  J Tissue Eng Regen Med     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308490     Medline TA:  J Tissue Eng Regen Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 John Wiley & Sons, Ltd.
Affiliation:
Bone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Human Development and Health, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prevalence of Lipodystrophy in HIV-Infected Children in Tanzania on HAART.
Next Document:  Patterns of molecular motors that guide and sort filaments.