Document Detail

From angiotensin IV binding site to AT4 receptor.
MedLine Citation:
PMID:  19071192     Owner:  NLM     Status:  MEDLINE    
One of the fragments of the cardiovascular hormone Angiotensin II incited the interest of several research groups. This 3-8 fragment, denoted as Angiotensin IV (Ang IV) causes a number of distinct biological effects (see Introduction), unlikely to be explained by its weak binding to AT(1) and/or AT(2) receptors. Moreover the discovery of high affinity [(125)I]-Ang IV binding sites and their particular tissue distribution led to the concept of the AT(4) receptor. An important breakthrough was achieved by defining the AT(4) receptor as the membrane-bound insulin-regulated aminopeptidase (IRAP). Crucial for the definition as a receptor the binding of the endogenous ligand(s) should be linked to particular cellular and/or biochemical processes. With this respect, cultured cells offer the possibility to study the presence of binding sites in conjunction with ligand induced signaling. This link is discussed for the AT(4) receptor by providing an overview of the cellular effects by AT(4) ligands.
Patrick M L Vanderheyden
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-21
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  302     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-31     Completed Date:  2009-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  159-66     Citation Subset:  IM    
Department of Molecular and Biochemical Pharmacology, Vrije Universiteit Brussel, Brussels, Belgium.
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MeSH Terms
Angiotensin II / analogs & derivatives*,  chemistry,  metabolism
Binding Sites
Receptors, Angiotensin / metabolism*
Signal Transduction
Reg. No./Substance:
0/AT4 receptor; 0/Receptors, Angiotensin; 11128-99-7/Angiotensin II; 23025-68-5/angiotensin II, des-Asp(1)-des-Arg(2)-Ile(5)-

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