Document Detail

From vascular corrosion cast to electrical analog model for the study of human liver hemodynamics and perfusion.
MedLine Citation:
PMID:  20709637     Owner:  NLM     Status:  In-Data-Review    
Hypothermic machine perfusion (HMP) is experiencing a revival in organ preservation due to the limitations of static cold storage and the need for better preservation of expanded criteria donor organs. For livers, perfusion protocols are still poorly defined, and damage of sinusoidal endothelial cells and heterogeneous perfusion are concerns. In this study, an electrical model of the human liver blood circulation is developed to enlighten internal pressure and flow distributions during HMP. Detailed vascular data on two human livers, obtained by combining vascular corrosion casting, micro-CT-imaging and image processing, were used to set up the electrical model. Anatomical data could be measured up to 5--6 vessel generations in each tree and showed exponential trend lines, used to predict data for higher generations. Simulated flow and pressure were in accordance with literature data. The model was able to simulate effects of pressure-driven HMP on liver hemodynamics and reproduced observations such as flow competition between the hepatic artery and portal vein. Our simulations further indicate that, from a pure biomechanical (shear stress) standpoint, HMP with low pressures should not result in organ damage, and that fluid viscosity has no effect on the shear stress experienced by the liver microcirculation in pressure-driven HMP.
Charlotte Debbaut; Diethard Monbaliu; Christophe Casteleyn; Pieter Cornillie; Denis Van Loo; Bert Masschaele; Jacques Pirenne; Paul Simoens; Luc Van Hoorebeke; Patrick Segers
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Publication Detail:
Type:  Journal Article     Date:  2010-08-12
Journal Detail:
Title:  IEEE transactions on bio-medical engineering     Volume:  58     ISSN:  1558-2531     ISO Abbreviation:  IEEE Trans Biomed Eng     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0012737     Medline TA:  IEEE Trans Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-35     Citation Subset:  IM    
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