Document Detail


From T-cell activation signals to signaling control of anti-cancer immunity.
MedLine Citation:
PMID:  17979845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The activation of resting T cells is crucial to most immune processes. Recognition of foreign antigen by T-cell receptors has to be correctly translated into signal transduction events necessary for the induction of an effective immune response. In this review, we discuss the essential signals, molecules, and processes necessary to achieve full T-cell activation. In addition to describing these key biological events, we also discuss how T-cell receptor signaling may be harnessed to yield new therapeutic targets for a next generation of anti-cancer drugs.
Authors:
Shane J F Cronin; Josef M Penninger
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunological reviews     Volume:  220     ISSN:  0105-2896     ISO Abbreviation:  Immunol. Rev.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-05     Completed Date:  2008-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7702118     Medline TA:  Immunol Rev     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  151-68     Citation Subset:  IM    
Affiliation:
IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Humans
Isoenzymes / metabolism
Lymphocyte Activation*
Mice
Neoplasms / immunology*
Protein Kinase C / metabolism
Proto-Oncogene Proteins c-cbl / metabolism
Receptors, Antigen, T-Cell / metabolism
Signal Transduction*
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Isoenzymes; 0/Receptors, Antigen, T-Cell; 148374-93-0/PRKCQ protein, human; EC 2.7.11.13/Protein Kinase C; EC 6.3.2.-/Proto-Oncogene Proteins c-cbl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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