Document Detail

From Src Homology domains to other signaling modules: proposal of the 'protein recognition code'.
MedLine Citation:
PMID:  9779993     Owner:  NLM     Status:  MEDLINE    
The study of oncogenes has illuminated many aspects of cellular signaling. The delineation and characterization of protein modules exemplified by Src Homology domains has revolutionized our understanding of the molecular events underlying signal transduction pathways. Several well characterized intracellular modules which mediate protein-protein interactions, namely SH2, SH3, PH, PTB, EH, PDZ, EVH1 and WW domains, are directly involved in the multitude of membrane, cytoplasmic and nuclear processes in multicellular and/or unicellular organisms. The modular character of these protein domains and their cognate motifs, the universality of their molecular function, their widespread occurrence, and the specificity as well as the degeneracy of their interactions have prompted us to propose the concept of the 'protein recognition code'. By a parallel analogy to the universal genetic code, we propose here that there will be a finite set of precise rules to govern and predict protein-protein interactions mediated by modules. Several rules of the 'protein recognition code' have already emerged.
M Sudol
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Oncogene     Volume:  17     ISSN:  0950-9232     ISO Abbreviation:  Oncogene     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-11-23     Completed Date:  1998-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1469-74     Citation Subset:  IM    
The Department of Biochemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.
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MeSH Terms
Binding Sites
Models, Biological*
Phosphotyrosine / metabolism
Proteins / genetics*,  metabolism*
Signal Transduction*
src Homology Domains*
Reg. No./Substance:
0/Proteins; 21820-51-9/Phosphotyrosine

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