Document Detail


From metabolism to ecology: cross-feeding interactions shape the balance between polymicrobial conflict and mutualism.
MedLine Citation:
PMID:  23070318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Polymicrobial interactions are widespread in nature and play a major role in maintaining human health and ecosystems. Whenever one organism uses metabolites produced by another organism as energy or nutrient sources, it is called cross-feeding. The ecological outcomes of cross-feeding interactions are poorly understood and potentially diverse: mutualism, competition, exploitation, or commensalism. A major reason for this uncertainty is the lack of theoretical approaches linking microbial metabolism to microbial ecology. To address this issue, we explore the dynamics of a one-way interspecific cross-feeding interaction in which food can be traded for a service (detoxification). Our results show that diverse ecological interactions (competition, mutualism, exploitation) can emerge from this simple cross-feeding interaction and can be predicted by the metabolic, demographic, and environmental parameters that govern the balance of the costs and benefits of association. In particular, our model predicts stronger mutualism for intermediate by-product toxicity because the resource-service exchange is constrained to the service being neither too vital (high toxicity impairs resource provision) nor dispensable (low toxicity reduces need for service). These results support the idea that bridging microbial ecology and metabolism is a critical step toward a better understanding of the factors governing the emergence and dynamics of polymicrobial interactions.
Authors:
Sylvie Estrela; Christopher H Trisos; Sam P Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-28
Journal Detail:
Title:  The American naturalist     Volume:  180     ISSN:  1537-5323     ISO Abbreviation:  Am. Nat.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-16     Completed Date:  2013-02-19     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  2984688R     Medline TA:  Am Nat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  566-76     Citation Subset:  IM    
Affiliation:
Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, West Mains Road, Edinburgh EH9 3JT, United Kingdom. s.estrela@sms.ed.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Bacteria / metabolism*
Ecology
Humans
Microbial Interactions / physiology*
Models, Biological*
Symbiosis*
Grant Support
ID/Acronym/Agency:
082273//Wellcome Trust; 082273/Z/07/Z//Wellcome Trust
Comments/Corrections

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