Document Detail

From MALT lymphoma to the CBM signalosome: three decades of discovery.
MedLine Citation:
PMID:  21750409     Owner:  NLM     Status:  MEDLINE    
The advent of molecular cytogenetics has led to the elucidation of genetic abnormalities that cause various congenital and oncological disorders. In B cell lymphoma, for example, a number of chromosomal translocations have been identified in and associated with the etiology of specific subtypes of lymphoma. Several recurrent chromosomal translocations have been identified in extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Cloning and characterization of the products of three mutually exclusive translocation breakpoints found in MALT lymphoma led to the discovery of a novel NF-κB-activating complex comprising the CARMA, Bcl10, and MALT1 proteins. This "CBM signalosome" acts downstream of the antigen receptors in lymphocytes as well as a number of non-lymphoid cell-surface receptors involved in a variety of biological processes. CBM signalosome activity is important for normal cellular functions and is perturbed in neoplastic and inflammatory disorders, making it a viable target for novel therapeutic design.
Shaun Rosebeck; Aasia O Rehman; Peter C Lucas; Linda M McAllister-Lucas
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-08-01
Journal Detail:
Title:  Cell cycle (Georgetown, Tex.)     Volume:  10     ISSN:  1551-4005     ISO Abbreviation:  Cell Cycle     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-26     Completed Date:  2011-12-13     Revised Date:  2013-12-11    
Medline Journal Info:
Nlm Unique ID:  101137841     Medline TA:  Cell Cycle     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2485-96     Citation Subset:  IM    
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MeSH Terms
Adaptor Proteins, Signal Transducing / metabolism*,  physiology
CARD Signaling Adaptor Proteins / metabolism*,  physiology
Caspases / metabolism*,  physiology
Chromosomes / metabolism
Lymphoma, B-Cell, Marginal Zone / metabolism*,  pathology
NF-kappa B / metabolism
Neoplasm Proteins / metabolism*,  physiology
Signal Transduction*
Grant Support
R01 CA124540/CA/NCI NIH HHS; R01 CA124540-04/CA/NCI NIH HHS; R01 CA124540-05/CA/NCI NIH HHS; R01 DK079973-04/DK/NIDDK NIH HHS; R01 HL082914/HL/NHLBI NIH HHS; R01 HL082914-05/HL/NHLBI NIH HHS; R01CA124540/CA/NCI NIH HHS; R01DK079973/DK/NIDDK NIH HHS; R01HL082914/HL/NHLBI NIH HHS; T32-HL007622-21A2/HL/NHLBI NIH HHS
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/BCL10 protein, human; 0/CARD Signaling Adaptor Proteins; 0/NF-kappa B; 0/Neoplasm Proteins; EC 3.4.22.-/Caspases; EC 3.4.22.-/MALT1 protein, human

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