| From MALT lymphoma to the CBM signalosome: three decades of discovery. | |
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MedLine Citation:
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PMID: 21750409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The advent of molecular cytogenetics has led to the elucidation of genetic abnormalities that cause various congenital and oncological disorders. In B cell lymphoma, for example, a number of chromosomal translocations have been identified in and associated with the etiology of specific subtypes of lymphoma. Several recurrent chromosomal translocations have been identified in extranodal marginal zone B cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). Cloning and characterization of the products of three mutually exclusive translocation breakpoints found in MALT lymphoma led to the discovery of a novel NF-κB-activating complex comprising the CARMA, Bcl10, and MALT1 proteins. This "CBM signalosome" acts downstream of the antigen receptors in lymphocytes as well as a number of non-lymphoid cell-surface receptors involved in a variety of biological processes. CBM signalosome activity is important for normal cellular functions and is perturbed in neoplastic and inflammatory disorders, making it a viable target for novel therapeutic design. |
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Authors:
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Shaun Rosebeck; Aasia O Rehman; Peter C Lucas; Linda M McAllister-Lucas |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2011-08-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 10 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-26 Completed Date: 2011-12-13 Revised Date: 2012-09-25 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 2485-96 Citation Subset: IM |
Affiliation:
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Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptor Proteins, Signal Transducing
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metabolism*,
physiology CARD Signaling Adaptor Proteins / metabolism*, physiology Caspases / metabolism*, physiology Chromosomes / metabolism Humans Lymphoma, B-Cell, Marginal Zone / metabolism*, pathology NF-kappa B / metabolism Neoplasm Proteins / metabolism*, physiology Signal Transduction* |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA124540/CA/NCI NIH HHS; R01 CA124540-04/CA/NCI NIH HHS; R01 CA124540-05/CA/NCI NIH HHS; R01 DK079973-04/DK/NIDDK NIH HHS; R01 HL082914-05/HL/NHLBI NIH HHS; R01CA124540/CA/NCI NIH HHS; R01DK079973/DK/NIDDK NIH HHS; R01HL082914/HL/NHLBI NIH HHS; T32-HL007622-21A2/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adaptor Proteins, Signal Transducing; 0/BCL10 protein, human; 0/CARD Signaling Adaptor Proteins; 0/NF-kappa B; 0/Neoplasm Proteins; EC 3.4.22.-/Caspases; EC 3.4.22.-/MALT1 protein, human |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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