Document Detail


From GH to Billy Ghrelin.
MedLine Citation:
PMID:  19656485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The octanoylated peptide hormone ghrelin regulates episodic growth hormone release and energy balance. Work in genetically modified mice (Kirchner et al., 2009) now shows that in vivo activity of ghrelin O-acyltransferase (GOAT), responsible for ghrelin octanoylation, decreases during fasting but increases after ingesting medium-chain fatty acid triglycerides (MCT).
Authors:
Roy G Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell metabolism     Volume:  10     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-06     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  82-3     Citation Subset:  IM    
Affiliation:
Department of Metabolism and Aging, The Scripps Research Institute Florida, Jupiter, FL 33458, USA. rgsmith@scripps.edu
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MeSH Terms
Descriptor/Qualifier:
Acyltransferases / deficiency,  genetics,  metabolism
Animals
Fasting
Ghrelin / genetics,  metabolism*
Growth Hormone / metabolism*
Mice
Mice, Transgenic
Receptors, Ghrelin / metabolism
Chemical
Reg. No./Substance:
0/Ghrelin; 0/Receptors, Ghrelin; 9002-72-6/Growth Hormone; EC 2.3.-/Acyltransferases; EC 2.3.-/ghrelin O-acyltransferase, mouse

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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