| From G-quartets to G-ribbon gel by concentration and sonication control. | |
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MedLine Citation:
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PMID: 23354390 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Two guanosine analogues have been designed and synthesized by connecting one () or three adamantane branches (). The compound containing a single adamantane branch formed G-quartets in acetonitrile solution, and was then transformed into a G-ribbon gel at concentrations higher than the critical gelation concentration. In contrast, the compound with three adamantane branches precipitated after a heating-cooling process. By means of circular dichroism and UV/visible spectra, NMR, SEM, and structural studies, the mechanism of the formation of the G-quartets and G-ribbon gel, as well as the difference in the self-assembly modes of the two compounds, have been fully elucidated. Compound firstly self-assembled into G-quartets in solutions in the concentration range 5.0 × 10(-4) to 1.0 × 10(-2) M, and these G-quartets were transformed into a G-ribbon on further increasing the concentration. Gelation occurred when the G-ribbon self-assembled into a hexagonal columnar structure with the help of intermolecular hydrogen-bonding and hydrophobic interactions. This gel was sensitive to sonication and underwent a morphology change from a columnar structure to a flower-like structure composed of flakes. In contrast, due to steric hindrance, compound only assembled into a spherical structure based on hydrophobic interactions. |
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Authors:
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Luyan Meng; Keyin Liu; Shuli Mo; Yueyuan Mao; Tao Yi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
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Title: Organic & biomolecular chemistry Volume: - ISSN: 1477-0539 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101154995 Medline TA: Org Biomol Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China. yitao@fudan.edu.cn. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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