| Friend or foe: using systems biology to elucidate interactions between fungi and their hosts. | |
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MedLine Citation:
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PMID: 21871806 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Modelling the networks sustaining the fruitful coexistence between fungi and their mammalian hosts is becoming increasingly important to control emerging fungal pathogens. In a 'systems biology' perspective, the microbiota and host should be seen as an ecosystem, and disease considered as an alteration of the equilibrium. This review addresses host-fungus interaction with a special focus on systems biology approaches to investigate the mechanisms developed by Candida albicans and Aspergillus fumigatus to circumvent host immune responses during fungal infections. Such genome-wide integrative approaches hold the promise to significantly improve our ability to understand which fungal traits can be considered potential threats and the regulatory networks involved in immune subversion. |
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Authors:
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Lisa Rizzetto; Duccio Cavalieri |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-24 |
Journal Detail:
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Title: Trends in microbiology Volume: - ISSN: 1878-4380 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9310916 Medline TA: Trends Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Preclinical and Clinical Pharmacology, University of Florence, viale Pieraccini 6, 50139 Firenze, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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