Document Detail

The fried frailty criteria as inclusion criteria for a randomized controlled trial: personal experience and literature review.
MedLine Citation:
PMID:  20407227     Owner:  NLM     Status:  In-Process    
BACKGROUND: among current operational definitions of frailty, the criteria proposed by Fried and colleagues have attracted great scientific interest. However, these criteria have usually been applied in epidemiological and only rarely in interventional studies.
OBJECTIVE: the present paper aims at testing the applicability of the Fried frailty criteria in the context of the recruitment process of a randomized controlled trial in prefrail older persons, and it discusses the respective scientific literature.
METHODS: recruitment was promoted by newspaper articles as well as by targeted mail to customers of a local health insurance company and to recently treated patients of a geriatric day clinic. Furthermore, presentations were given in assisted living facilities. Potential candidates were screened for prefrailty, i.e. to see whether they met 1 or 2 of the Fried criteria (weight loss, handgrip strength, gait speed, exhaustion, physical activity).
RESULTS: a total of 298 people were screened. Among them 181 were not frail, 116 were prefrail and 1 was diagnosed as frail. The most prevalent criterion was exhaustion (24% of those screened). The second most prevalent criterion was low handgrip strength (20%). Low gait speed (8%), low physical activity (2%) and weight loss (2%) had a lower prevalence. According to the Geriatric Depression Scale, 14% of those who met the criterion 'exhaustion' were depressed. With regard to the Minnesota Leisure Time Physical Activity Questionnaire, used for the evaluation of 'physical activity', only 3 activities among the 18 selected by Fried were applicable to our cohort.
CONCLUSIONS: under the study conditions, good applicability of the Fried criteria was observed. Nevertheless, further refinement may be expedient in several criteria, especially exhaustion and physical activity, to enhance clinical usefulness. It may be helpful to adapt the cutoffs when applying the criteria to a European population.
M Drey; K Pfeifer; C C Sieber; J M Bauer
Related Documents :
2265887 - Self-report symptoms that predict major depression in patients with prominent physical ...
23076097 - Loss of consciousness, depression, posttraumatic stress disorder, and suicide risk amon...
23416877 - Stress generation: future directions and clinical implications.
3267827 - Alexithymia: subscales and relationship to depression.
11128667 - Validity of the mactar questionnaire as a functional index in a rheumatoid arthritis cl...
11059947 - Fenoterol hydrobromide delivered via hfa-mdi or cfc-mdi in patients with asthma: a safe...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-21
Journal Detail:
Title:  Gerontology     Volume:  57     ISSN:  1423-0003     ISO Abbreviation:  Gerontology     Publication Date:  2011  
Date Detail:
Created Date:  2010-12-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7601655     Medline TA:  Gerontology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  IM    
Copyright Information:
2010 S. Karger AG, Basel.
Department of Geriatric Medicine, University of Erlangen-Nuremberg, Nuremberg, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Slow cooling cryopreservation of cell-microcarrier constructs.
Next Document:  Autoimmune polyglandular syndrome type 1 in Russian patients: clinical variants and autoimmune regul...