Document Detail

Frictional properties of poly(MPC-co-BMA) phospholipid polymer for catheter applications.
MedLine Citation:
PMID:  14568428     Owner:  NLM     Status:  MEDLINE    
A fundamental understanding of surface properties of the biomaterials at a nanometer scale should be generated in order to understand cellular responses of the tissue to biomaterials thereby minimizing or eliminating tissue trauma at a macrometer scale. In this study poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate) ([poly(MPC-co-BMA]) was evaluated as a potential coating material for vascular applications to provide smooth catheterization using atomic force microscopy (AFM) techniques.A uniform coating of [poly(MPC-co-BMA] equivalent to a thickness of 2.5 microm on a polyurethane (PU) catheter material was provided using dip casting technique. Using a contact mode AFM, no significant difference in surface roughness (R(a)) and frictional force (f) between uncoated (R(a)=10.2+/-1.9 nm, f=0.907+/-0.02) and coated (R(a)=11.7+/-1.8 nm, f=0.930+/-0.06) surfaces was observed under dry conditions. However, under wet conditions the R(a) of the coated surface (3.4+/-1.0 nm) was significantly lower than uncoated PU surface (9.0+/-1.8 nm). The coating on PU substrate offered the least frictional resistance (f=0.004+/-0.001) illustrating enhanced boundary lubrication capability due to hydration of phosphorylcholine polymer as compared to a significantly higher f for uncoated PU (0.017+/-0.007) surfaces. These tribological and chemical characteristics of the [poly(MPC-co-BMA)] coating could increase the overall efficacy of PU for clinical applications.
Sunita P Ho; Nobuo Nakabayashi; Yasuhiko Iwasaki; Thomas Boland; Martine LaBerge
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biomaterials     Volume:  24     ISSN:  0142-9612     ISO Abbreviation:  Biomaterials     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-10-21     Completed Date:  2004-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8100316     Medline TA:  Biomaterials     Country:  England    
Other Details:
Languages:  eng     Pagination:  5121-9     Citation Subset:  IM    
Department of Preventive and Restorative Dental Sciences, University of California San Francisco, Box 0758 D2254, San Francisco, CA 94143, USA.
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MeSH Terms
Catheterization / instrumentation*
Coated Materials, Biocompatible / chemical synthesis*
Materials Testing / methods*
Methacrylates / chemistry*
Microscopy, Atomic Force / methods*
Phosphorylcholine / analogs & derivatives*,  chemistry*
Stress, Mechanical
Surface Properties
Water / chemistry*
Reg. No./Substance:
0/Coated Materials, Biocompatible; 0/Methacrylates; 107-73-3/Phosphorylcholine; 125275-25-4/poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate); 7732-18-5/Water

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