Document Detail

Fresh motile testicular sperm retrieved from nonobstructive azoospermic patients has the same potential to achieve fertilization and pregnancy via ICSI as sperm retrieved from obstructive azoospermic patients.
MedLine Citation:
PMID:  18343377     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the fertilization and pregnancy rates using fresh testicular sperm between nonobstructive azoospermic (NOA) patients and obstructive azoospermic (OA) patients. DESIGN: We evaluated sperm quality of testicular sperm retrieved by microdissection testicular sperm extraction (MD-TESE) in NOA patients and compared the fertilization rate and pregnancy rate via intracytoplasmic sperm injection (ICSI) between NOA and OA patients. SETTING: Private hospital-based infertility research laboratory. PATIENT(S): A total of 58 couples in which the husband was diagnosed with azoospermia. INTERVENTION(S): Analytic examination of the outcomes and description of the NOA cases achieving pregnancies; oocyte retrieval and testicular sperm retrieval were performed simultaneously. MAIN OUTCOME MEASURE(S): Comparison of fertilization rate and pregnancy rate at the first ICSI attempt. RESULT(S): Testicular sperm were retrieved from 17 of 40 NOA patients and 18 of 18 OA patients. Motile sperm were successfully retrieved from 16 of the 17 NOA patients. There was no significant difference in fertilization rate and pregnancy rate between OA and NOA cases. Of the 17 NOA patients, nine pregnancies were achieved using fresh motile testicular sperm. CONCLUSION(S): Fresh motile testicular sperm retrieved from NOA patients may have the same potential to achieve fertilization and pregnancy as sperm retrieved from OA patients. The MD-TESE technique might contribute to the high retrieval rate of fresh motile testicular sperm even in NOA patients.
Satoru Kanto; Junichi Sugawara; Hiroshi Masuda; Hironobu Sasano; Yoichi Arai; Koichi Kyono
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-03-17
Journal Detail:
Title:  Fertility and sterility     Volume:  90     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-10     Completed Date:  2008-12-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2010.e5-7     Citation Subset:  IM    
Kyono ART Clinic and Reproduction Center, Tohoku University Graduate School of Medicine, Sendai, Japan.
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MeSH Terms
Azoospermia / physiopathology,  therapy*
Embryo Transfer
Oocyte Retrieval
Pregnancy Rate
Retrospective Studies
Sperm Injections, Intracytoplasmic*
Sperm Motility*
Sperm Retrieval*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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