| Fresh-frozen plasma as a source of exogenous insulin-like growth factor-I in the extremely preterm infant. | |
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MedLine Citation:
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PMID: 19001522 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Preterm birth is followed by a decrease in circulatory levels of IGF-I and IGF binding protein (IGFBP)-3, proteins with important neurogenic and angiogenic properties. OBJECTIVE: Our objective was to evaluate the effects of iv administration of fresh-frozen plasma (FFP) from adult donors on circulatory levels of IGF-I and IGFBP-3 in extremely preterm infants. DESIGN, SETTING, AND PATIENTS: A prospective cohort study was performed in 20 extremely preterm infants [mean (SD) gestational age 25.3 (1.3) wk] with clinical requirement of FFP during the first postnatal week. Sampling was performed before initiation of transfusion, directly after, and at 6, 12, 24, and 48 h after completed FFP transfusion. MAIN OUTCOME MEASURES: Concentrations of IGF-I and IGFBP-3 before and after transfusion of FFP were determined. RESULTS: FFP with a mean (SD) volume of 11 ml/kg (3.1) was administered at a median postnatal age of 2 d (range 1-7). Mean (SD) IGF-I and IGFBP-3 concentrations in administered FFP were 130 (39) and 2840 microg/liter (615), respectively. Immediately after FFP transfusion, mean (SD) concentrations of IGF-I increased by 133% from 11 (6.4) to 25 microg/liter (9.3) (P < 0.001) and IGFBP-3 by 61% from 815 (451) to 1311 microg/liter (508) (P < 0.001). Concentrations of IGF-I and IGFBP-3 remained higher at 6 (P < 0.001, P = 0.009) and 12 h (P = 0.017, P = 0.018), respectively, as compared with concentrations before FFP transfusion. Typical half-life of administrated IGF-I was 3.4 h for a 1-kg infant. CONCLUSION: Transfusion of FFP to extremely preterm infants during the first postnatal week elevates levels of IGF-I and IGFBP-3. |
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Authors:
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Ingrid Hansen-Pupp; Eva Engström; Aimon Niklasson; Ann-Cathrine Berg; Vineta Fellman; Chatarina Löfqvist; Ann Hellström; David Ley |
Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-11 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 94 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-05 Completed Date: 2009-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 477-82 Citation Subset: AIM; IM |
Affiliation:
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Division of Pediatrics, Department of Clinical Sciences Lund, Lund University Hospital, 221 85 Lund, Sweden. ingrid.pupp@skane.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Glucose
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analysis Blood Transfusion* / methods Combined Modality Therapy Gestational Age Humans Infant, Extremely Low Birth Weight* / blood Infant, Newborn Insulin-Like Growth Factor Binding Proteins / analysis, blood Insulin-Like Growth Factor I / administration & dosage*, analysis, deficiency Parenteral Nutrition Plasma* / chemistry, physiology Premature Birth / blood, therapy* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/IGFBP3 protein, human; 0/Insulin-Like Growth Factor Binding Proteins; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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