Document Detail

Fresh Frozen Plasma for Progressive and Refractory Angiotensin-Converting Enzyme Inhibitor-induced Angioedema.
MedLine Citation:
PMID:  23114109     Owner:  NLM     Status:  Publisher    
BACKGROUND: Angioedema secondary to angiotensin-converting enzyme inhibitors (ACEI) is a commonly encountered problem in the Emergency Department (ED). The treatment of ACEI-induced edema with conventional methods such as epinephrine, steroids, and antihistamines is usually not effective. There is limited experience using bradykinin receptor blockers and fresh frozen plasma (FFP) as a treatment modality for ACEI-induced angioedema. OBJECTIVE: To emphasize alternative treatment option for ACEI-induced angioedema in the ED. CASE REPORTS: We report a case series of progressive and refractory presumed ACEI-induced angioedema that all improved in temporal association with administration of FFP, with a brief review of the literature. CONCLUSION: There was a temporal association between the administration of FFP and improvement in angioedema in seven cases of presumed ACEI-induced angioedema that were refractory to antihistamines, corticosteroids, and epinephrine.
Getaw Worku Hassen; Hossein Kalantari; Monica Parraga; Roger Chirurgi; Carlos Meletiche; Christopher Chan; Jacque Ciarlo; Farhad Gazi; Christopher Lobaito; Siamak Tadayon; Selamawit Yemane; Carolina Velez
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-28
Journal Detail:
Title:  The Journal of emergency medicine     Volume:  -     ISSN:  0736-4679     ISO Abbreviation:  J Emerg Med     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8412174     Medline TA:  J Emerg Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Published by Elsevier Inc.
Department of Emergency Medicine, New York Medical College, Metropolitan Hospital Center, New York, New York.
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