Document Detail

Frequent triptan use: observations on safety issues.
MedLine Citation:
PMID:  14756859     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the safety of frequent triptan use over extended periods. For a small group of patients with refractory migraine plus chronic daily headache, triptans are effective. METHODS: This retrospective study primarily evaluated the cardiac safety of daily triptan use in 118 patients and, in addition, hematologic tests were assessed. Each patient had utilized a triptan for a minimum of 4 days per week for at least 6 months. Patients with rebound headache had been withdrawn from the triptans. Most patients (97 of 118) averaged 1 tablet daily; most would occasionally go for several days without a triptan. Forty patients had taken a triptan for 6 months to 2 years, 37 patients from 2 to 4 years, and 41 for 4 or more years. RESULTS: Routine hematologic tests were performed periodically on all patients, and no abnormalities were attributable to triptans. Almost all patients had an electrocardiogram, and no abnormal electrocardiograms were felt to be related to triptans. Cardiac echocardiography was performed in 57 patients. The 10 abnormal echocardiograms were not due to triptans. All 20 cardiac stress tests revealed normal findings. Adverse events were minimal; 9 patients described fatigue due to triptans, and 5 had mild chest tightness. CONCLUSION: This long-term study of 118 patients indicates that frequent triptan use may be relatively safe.
L Robbins
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Headache     Volume:  44     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-03     Completed Date:  2004-05-17     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  178-82     Citation Subset:  IM    
Department of Neurology, Rush Medical College, Chicago, Ill. 60062, USA.
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MeSH Terms
Headache Disorders / drug therapy*
Middle Aged
Migraine Disorders / drug therapy*
Retrospective Studies
Self Medication*
Serotonin Agonists / administration & dosage*,  adverse effects*
Reg. No./Substance:
0/Serotonin Agonists

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