Document Detail


Frequent sampling allows detection of short and rapid surges of exhaled ethane during cardiac surgery.
MedLine Citation:
PMID:  18666741     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During cardiopulmonary bypass (CPB), hypoperfusion and reperfusion may cause oxidative stress and lipid peroxidation that generates ethane. The aim of this pilot study was to assess the feasibility of frequent sampling of exhaled ethane during cardiac surgery. After approval of the Research Ethics Committee, 10 patients undergoing combined aortic valve and coronary artery bypass surgery were enrolled. Breath samples were drawn in the perioperative period and analyzed by a rapid, sensitive and validated gas-chromatographic method. Increased exhaled ethane was regularly seen following sternotomy, after the start of CPB and after aortic clamp removal, whereas no change was seen after termination of bypass. In one patient, the maximum increase in exhaled ethane was 30-fold. Peak durations lasted only 2-4 min. This study demonstrates that frequent sampling of breath ethane is feasible in a clinical setting, allowing detection of rapid ethane surges of short duration.
Authors:
R Stenseth; T Nilsen; R Haaverstad; N Vitale; O Dale
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Perfusion     Volume:  22     ISSN:  0267-6591     ISO Abbreviation:  Perfusion     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2008-07-31     Completed Date:  2008-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700166     Medline TA:  Perfusion     Country:  England    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Affiliation:
Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. roar.stenseth@ntnu.no
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Aortic Valve / surgery
Breath Tests
Cardiopulmonary Bypass*
Coronary Artery Bypass*
Ethane / analysis*
Exhalation
Female
Heart Diseases / surgery*
Heart Valve Prosthesis Implantation
Humans
Lipid Peroxidation
Male
Middle Aged
Oxidative Stress
Pilot Projects
Pulmonary Gas Exchange
Chemical
Reg. No./Substance:
74-84-0/Ethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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