| Frequent sampling allows detection of short and rapid surges of exhaled ethane during cardiac surgery. | |
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MedLine Citation:
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PMID: 18666741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During cardiopulmonary bypass (CPB), hypoperfusion and reperfusion may cause oxidative stress and lipid peroxidation that generates ethane. The aim of this pilot study was to assess the feasibility of frequent sampling of exhaled ethane during cardiac surgery. After approval of the Research Ethics Committee, 10 patients undergoing combined aortic valve and coronary artery bypass surgery were enrolled. Breath samples were drawn in the perioperative period and analyzed by a rapid, sensitive and validated gas-chromatographic method. Increased exhaled ethane was regularly seen following sternotomy, after the start of CPB and after aortic clamp removal, whereas no change was seen after termination of bypass. In one patient, the maximum increase in exhaled ethane was 30-fold. Peak durations lasted only 2-4 min. This study demonstrates that frequent sampling of breath ethane is feasible in a clinical setting, allowing detection of rapid ethane surges of short duration. |
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Authors:
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R Stenseth; T Nilsen; R Haaverstad; N Vitale; O Dale |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Perfusion Volume: 22 ISSN: 0267-6591 ISO Abbreviation: Perfusion Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2008-07-31 Completed Date: 2008-09-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700166 Medline TA: Perfusion Country: England |
Other Details:
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Languages: eng Pagination: 391-6 Citation Subset: IM |
Affiliation:
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Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway. roar.stenseth@ntnu.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Aortic Valve / surgery Breath Tests Cardiopulmonary Bypass* Coronary Artery Bypass* Ethane / analysis* Exhalation Female Heart Diseases / surgery* Heart Valve Prosthesis Implantation Humans Lipid Peroxidation Male Middle Aged Oxidative Stress Pilot Projects Pulmonary Gas Exchange |
| Chemical | |
Reg. No./Substance:
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74-84-0/Ethane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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