Document Detail


Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma.
MedLine Citation:
PMID:  12393409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied the genomic status of BCL6 in 23 cases of nodular lymphocyte predominance Hodgkin lymphoma (NLPHL) and 40 cases of classical Hodgkin lymphoma (cHL), using dual-color interphase fluorescence in situ hybridization (FISH). The BCL6 rearrangement was identified in 48% of NLPHL cases and was not detected in cHL cases. As a confirmation, sequential or simultaneous immunohistochemistry (IHC) and FISH using CD20 or BCL6 antibodies and BCL6 DNA probes was performed in 8 NLPHL cases. The BCL6-associated translocations, t(3;22)(q27;q11), t(3;7)(q27;p12), and the most probable t(3;9)(q27;p13), were identified in 3 cases. A consistent expression of BCL6 protein in popcorn cells with the highest number of intensely stained cells in cases with a genomic BCL6 rearrangement was shown by IHC. These findings support the hypothesis of a germinal center B cell-derived origin of NLPHL, indicate a significant role of BCL6 in the pathogenesis of NLPHL, and provide further evidence of the genetic diversity underlying the pathogenesis of NLPHL and cHL.
Authors:
Iwona Wlodarska; Peet Nooyen; Brigitte Maes; José I Martin-Subero; Reiner Siebert; Patrick Pauwels; Chris De Wolf-Peeters; Anne Hagemeijer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2002-09-12
Journal Detail:
Title:  Blood     Volume:  101     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-01     Completed Date:  2003-04-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  706-10     Citation Subset:  AIM; IM    
Affiliation:
Center for Human Genetics, Catholic University of Leuven, Belgium.
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MeSH Terms
Descriptor/Qualifier:
B-Lymphocytes / pathology
DNA, Neoplasm / analysis
DNA-Binding Proteins / analysis,  genetics*
Diagnosis, Differential
Gene Rearrangement, T-Lymphocyte
Germinal Center / pathology
Hodgkin Disease / etiology,  genetics*,  pathology*
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence / methods
Incidence
Leukemia, Lymphocytic, Chronic, B-Cell / etiology,  genetics*,  pathology*
Molecular Diagnostic Techniques
Proto-Oncogene Proteins / analysis,  genetics*
Proto-Oncogene Proteins c-bcl-6
Transcription Factors / analysis,  genetics*
Translocation, Genetic
Chemical
Reg. No./Substance:
0/DNA, Neoplasm; 0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-bcl-6; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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