| Frequent left ventricular hypertrophy independent of blood pressure in 1851 pre-western Inuit. | |
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MedLine Citation:
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PMID: 21429492 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Elevated blood pressure is a risk factor for cardiovascular disease and may be detected by left ventricular hypertrophy (LVH) in electrocardiogram (ECG). Pre-western Inuit had frequent signs of LVH in ECG predominantly in the 3rd decade while a low occurrence of ischemic heart disease. METHODS: We evaluated the association between blood pressures and ECG signs of LVH, cardiac auscultation, and symptoms related to heart disease in the recently recovered data from the survey of 1851 Inuit conducted in 1962-1964 in East Greenland. RESULTS: The participation rate was 97%. Among the 812 Inuit aged 18years or above blood pressure was unaltered until the age of 39years (systolic, p=76; diastolic, p=0.36) and increased subsequently (both, p<0.001). Systolic blood pressure >140mmHg was more frequent when aged >40years (p<0.001) and diastolic blood pressure >90mmHg was more common in men (p<0.001) and in men and women aged >40years (p<0.001). ECG signs of LVH were more frequent in men (p<0.01) but the occurrence decreased from the age of 40years (p<0.01), and were not influenced by systolic (p=0.97), diastolic (p=0.87) or pulse pressure (p=0.69). CONCLUSIONS: Blood pressure rose only after the age of 40years in pre-western Inuit. Left ventricular hypertrophy peaked among 30-year olds and was independent of elevated blood pressure. It may be speculated that the common left ventricular hypertrophy was due to marked physical activity that contributed to the low occurrence of ischemic heart disease among pre-western Inuit. |
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Authors:
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Stig Andersen; Marie Kjærgaard; Marit Eika Jørgensen; Gert Mulvad; Jens Jørgen Kjærgaard |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-2 |
Journal Detail:
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Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Internal Medicine, Queen Ingrids Hospital, Nuuk, Greenland; Arctic Health Research Centre, Aalborg University Hospital, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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