Document Detail

Frequent handling in the neonatal intensive care unit and intraventricular hemorrhage.
MedLine Citation:
PMID:  2196354     Owner:  NLM     Status:  MEDLINE    
The association between periventricular-intraventricular hemorrhage (PV-IVH) and frequent handling resulting from various neonatal intensive care procedures and routine interventions was evaluated in a prospective clinical study. Inborn premature babies with birth weight less than or equal to 1500 gm (n = 156) who did not have PV-IVH or who had grade 1 PV-IVH at less than or equal to 1 hour were randomly assigned to the reduced manipulation protocol (n = 62) or to standard care (n = 94). A bedside microcomputer-based data acquisition system was used to monitor the duration of rest or the number of interventions per day. Infants assigned to receive reduced manipulation spent a significantly higher percentage of time each day at rest than did those who received standard manipulation (p less than 0.006). However, the incidence of grades 2 to 4 PV-IVH did not differ significantly (30% in the study vs 37% in the standard manipulation group). When we analyzed the effect of manipulation in relation to risk of PV-IVH, while taking into account other perinatal variables, standard manipulation was not associated with increased risk of grades 2 to 4 PV-IVH. However, low birth weight, maternal smoking, general anesthesia, early grade 1 PV-IVH, low hematocrit, lowest arterial oxygen pressure within the first 6 hours of life, and large base deficit at 6 hours of age all increased the relative risk of grades 2 to 4 PV-IVH.
H S Bada; S B Korones; E H Perry; K L Arheart; M Pourcyrous; J W Runyan; G D Anderson; H L Magill; C W Fitch; G W Somes
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  117     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1990-08-17     Completed Date:  1990-08-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  126-31     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Tennessee, Memphis.
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MeSH Terms
Cerebral Hemorrhage / diagnosis,  epidemiology*
Cerebral Ventricles* / pathology
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature*
Intensive Care Units, Neonatal
Intensive Care, Neonatal* / statistics & numerical data
Odds Ratio
Prospective Studies
Random Allocation
Regression Analysis
Tennessee / epidemiology
Time Factors
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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