| Frequent expression of Niban in head and neck squamous cell carcinoma and squamous dysplasia. | |
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MedLine Citation:
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PMID: 19536772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Niban was initially identified in the Eker rat, a model of renal carcinogenesis. We examined Niban expression in head and neck squamous cell carcinoma (HNSCC) and head and neck dysplastic lesions. METHODS: Using a polyclonal rabbit anti-human Niban antibody, 43 cases of HNSCC and 30 cases of head and neck squamous dysplasia were immuonohistochemically stained for Niban. Ancillary genetic studies were also performed. RESULTS: Forty-two of 43 HNSCCs (97.6%) and 20 of 30 (66.6%) dysplastic lesions were positively stained for Niban. The staining was generally less intense in cases of dysplasia than HNSCC. Three of 8 normal mucosal samples from drinker/smokers also showed weak Niban expression. Normal head and neck squamous epithelium from nondrinker/nonsmokers did not stained for Niban. Reverse transcription polymerase chain reaction results matched the immuonohistochemical results. CONCLUSION: The expression of Niban frequently begins in the early stages of head and neck squamous carcinoma and remains upregulated throughout the carcinogenic process. Niban may be a good molecular marker of HNSCC. |
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Authors:
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Shin Ito; Hiroaki Fujii; Toshiharu Matsumoto; Masaaki Abe; Katsuhisa Ikeda; Okio Hino |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Head & neck Volume: 32 ISSN: 1097-0347 ISO Abbreviation: Head Neck Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-04-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 96-103 Citation Subset: IM |
Affiliation:
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Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carcinoma, Squamous Cell / genetics*, pathology Cell Transformation, Neoplastic / genetics Gene Expression Regulation, Neoplastic Head and Neck Neoplasms / genetics*, pathology Humans Hyperplasia / genetics Immunohistochemistry Neoplasm Proteins / genetics* Predictive Value of Tests Reverse Transcriptase Polymerase Chain Reaction Sensitivity and Specificity Tumor Markers, Biological / genetics* |
| Chemical | |
Reg. No./Substance:
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0/FAM129A protein, human; 0/Neoplasm Proteins; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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