Document Detail


Frequent detection of parvovirus B19 genome in the myocardium of adult patients with idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  14689308     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aside from enteroviruses and other viruses, e.g., adenoviruses, which are known to be associated with idiopathic dilated cardiomyopathy (IDC), a cardiac tropism is also attributed to parvovirus B19 (PVB19). The purpose of the present study was to determine the prevalence of enterovirus, adenovirus and PVB19 genomes in the myocardium of adult patients with IDC and to analyze the significance of PVB19 with regard to the course of the disease, as compared to the other cardiotropic viruses. In 52 adult patients with IDC and 10 control patients with normal left ventricular ejection fraction (> or =55%) undergoing coronary artery bypass surgery, myocardial tissue samples were investigated for enteroviral RNA using polymerase chain reaction (PCR) and Southern blot hybridization of the PCR product. Specific nested PCR was used to assess the prevalence of adenovirus and PVB19 DNA, in addition to sequencing of the latter. The clinical and echocardiographic course of the disease was followed for a mean (+/- SD) period of 21.1+/-9.5 months. Fourteen of the 52 patients (27%) were enterovirus-positive, 2/52 (4%) patients were adenovirus-positive, 14/52 (27%) patients were PVB19-positive, 8/52 (15%) patients were enterovirus plus PVB19-positive, and in 14/52 (27%) patients no viral genomes were found. Six patients died during the follow-up period, without any significant difference between the patient groups: 1/14 (7%) in the enterovirus-positive, 0/2 (0%) in the adenovirus-positive, 2/14 (14%) in the PVB19-positive, 1/8 (12.5%) in the enterovirus plus PVB19-positive, and 2/14 (14%) in the virus-negative group. PVB19 genome was found in 4 of the 10 (40%) control patients, but no enterovirus or adenovirus genomes were detected in these patients. In conclusion, in the myocardium of patients with IDC, PVB19 is detectable as frequently as enteroviral genome. PVB19-positive patients with IDC have a rather favorable prognosis and do not differ significantly from the other virus-positive or virus-negative patient groups with respect to survival. Finally, the pathogenetic and prognostic significance of PVB19 in IDC still remains unclear.
Authors:
Ulrich Lotze; Renate Egerer; Christiane Tresselt; Brigitte Glück; Gudrun Dannberg; Axel Stelzner; Hans R Figulla
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Publication Detail:
Type:  Journal Article     Date:  2003-12-20
Journal Detail:
Title:  Medical microbiology and immunology     Volume:  193     ISSN:  0300-8584     ISO Abbreviation:  Med. Microbiol. Immunol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-10     Completed Date:  2004-07-27     Revised Date:  2007-02-21    
Medline Journal Info:
Nlm Unique ID:  0314524     Medline TA:  Med Microbiol Immunol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine I, Cardiology, Angiology, Pneumology, Hospital Waltershausen-Friedrichroda, Reinhardsbrunner Str. 14-17, 99894 Friedrichroda, Germany. Med1.Lotze@krankenhaus-waltershausen-friedrichroda.de
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MeSH Terms
Descriptor/Qualifier:
Adenoviridae / isolation & purification
Adult
Aged
Base Sequence
Biopsy
Cardiomyopathy, Dilated / virology*
Endocardium / virology*
Enterovirus / isolation & purification
Enterovirus Infections / virology
Female
Genome, Viral*
Humans
Male
Middle Aged
Molecular Sequence Data
Parvoviridae Infections / virology*
Parvovirus B19, Human / isolation & purification*
Sequence Analysis, DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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