Document Detail

Frequent or complex ventricular ectopy in apparently healthy subjects: a clinical study of 25 cases.
MedLine Citation:
PMID:  952258     Owner:  NLM     Status:  MEDLINE    
During 18 months, 25 asymptomatic apparently healthy subjects were consecutively studied because of electrocardiographic discovery of frequent (more than 3 beats/min) or complex (multiform, alternating or repetitive patterns) ventricular ectopy of unknown cause. History, physical examination, laboratory data, chest roentgenogram, vectorcardiogram, exercise testing, echocardiogram, His bundle electrogram and cardiac catheterization procedures were performed to detect cardiac abnormalities. Ventricular ectopy was studied with maximal exercise testing, 24 hour Holter recordings and antiarrhythmic drug regimens. The duration of ventricular ectopy ranged from 1 to 30 years (mean 6). Eighteen subjects had an apparently normal cardiac status, and seven had mild or suspected abnormalities. Ventricular ectopy was of predominantly right ventricular origin in 19 of 25 subjects, and disappeared during maximal exercise in 21 of 23 subjects. Characteristic frequent (mean 559 beats/hour) and complex (bigeminal, trigerminal or ventricular couplet) ectopic beats were consistently present in all subjects during a 24 hour diurnal cycle. Antiarrhythmic drug regimens were generally ineffective. Our data suggest that a clinical syndrome of frequent complex ventricular ectopy can occur in apparently healthy subjects. The etiology and natural history of this syndrome are undefined.
H L Kennedy; S J Underhill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  38     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1976 Aug 
Date Detail:
Created Date:  1976-10-02     Completed Date:  1976-10-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-8     Citation Subset:  AIM; IM    
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Arrhythmias, Cardiac / complications,  drug therapy,  physiopathology*
Bundle of His / physiopathology
Bundle-Branch Block / physiopathology
Exercise Test
Heart Ventricles / physiopathology*
Hyperlipidemias / complications
Hypertension / complications
Middle Aged
Smoking / complications
Reg. No./Substance:
0/Anti-Arrhythmia Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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