| Frequent Loss of Tumor Suppressor ARID1A Protein Expression in Adenocarcinomas/Adenosquamous Carcinomas of the Uterine Cervix. | |
| | |
MedLine Citation:
|
PMID: 22274316 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVES: Expression of ARID1A (the adenine, thymine-rich interactive domain 1A), a putative tumor suppressor, has recently been shown to be lost in several tumor types. This study investigated whether ARID1A expression was also lost in cervical squamous cell carcinomas and adenocarcinomas/adenosquamous carcinomas. METHODS: A total of 91 patients with cervical carcinoma were enrolled. Cervical carcinoma specimens were examined for ARID1A protein expression by immunohistochemistry. The correlations between the loss of ARID1A expression and clinicopathological characteristics, and prognosis were investigated. RESULTS: Using immunohistochemistry, the frequency of loss of ARID1A expression in adenocarcinomas/adenosquamous carcinomas (31.1% [14/45]) was significantly higher than that in squamous cell carcinomas (6.5% [3/46]; P = 0.0017). There was no significant association between the loss of ARID1A expression and International Federation of Gynecology and Obstetrics staging, lymphovascular space invasion, lymph node metastasis, age, and Ki-67 LI in cervical adenocarcinomas/adenosquamous carcinomas. Loss of ARID1A expression was not correlated with shorter overall/disease-free survival in cervical adenocarcinomas/adenosquamous carcinomas. CONCLUSIONS: In conclusion, this study provides the first evidence of the frequent loss of ARID1A protein expression in cervical adenocarcinomas/adenosquamous carcinomas. No significant differences between ARID1A positive and negative cases were observed with respect to any clinicopathological features examined. |
| | |
Authors:
|
Atsuko Katagiri; Kentaro Nakayama; Mohammed Tanjimur Rahman; Munmun Rahman; Hiroshi Katagiri; Masako Ishikawa; Tomoka Ishibashi; Kouji Iida; Yoshiro Otsuki; Satoru Nakayama; Kohji Miyazaki |
Related Documents
:
|
476576 - Prognostic value of estrogen receptors in primary breast cancer. 11077086 - Estrone and estradiol metabolism in vivo in human breast cysts. 171066 - Pathological review of breast lesions analyzed for estrogen receptor protein. 12227896 - Progestins and cancer. 17923856 - Psa recurrence after brachytherapy for seed misplacement: a double-blind radiologic and... 8646366 - Mt-mmp expression and localisation in human lung and breast cancers. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of gynecological cancer : official journal of the International Gynecological Cancer Society Volume: 22 ISSN: 1525-1438 ISO Abbreviation: Int. J. Gynecol. Cancer Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-01-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9111626 Medline TA: Int J Gynecol Cancer Country: United States |
Other Details:
|
Languages: eng Pagination: 208-12 Citation Subset: IM |
Affiliation:
|
*Department of Obstetrics and Gynecology, Shimane University School of Medicine, Shimane; Departments of †Pathology, and ‡Obstetrics and Gynecology, Seirei Hamamatsu General Hospital, Hamamatsu, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Association of interleukin 16 with the development of ovarian tumor and tumor-associated neoangiogen...
Next Document: Family History and Women With Ovarian Cancer: Is it Asked and Does it Matter?: An Observational Stu...