Document Detail

Frequent loss of nyctohemeral rhythm of intraocular pressure restored by nCPAP treatment in patients with severe apnea.
MedLine Citation:
PMID:  20937994     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess 24-hour intraocular pressure (IOP) and ocular perfusion pressure rhythms in newly diagnosed apneic patients before and after nasal continuous positive airway pressure (nCPAP) treatment. METHODS: Intraocular pressure (using a Tonopen XL) and ambulatory blood pressure, measured hourly for 24 hours, were analyzed in 18 consecutive patients with obstructive sleep apnea for nyctohemeral rhythmicity (cosinor model). Twelve of 18 patients were reassessed after nCPAP use. RESULTS: Before treatment, 28% of the patients with obstructive sleep apnea demonstrated a nocturnal acrophase, 22% a diurnal acrophase, and 50% absence of 24-hour rhythm of IOP. The ocular perfusion pressure rhythm was nocturnal in 78% of cases and absent in 22%. Using nCPAP, the mean (standard error of the mean) nocturnal IOP increased from 14.8 (0.8) to 18.3 (1.2) mm Hg (P < .03). Among patients with initial abnormal IOP rhythm (ie, rhythm with diurnal acrophase or absence of rhythm), 67% shifted to a normal 24-hour IOP profile after treatment. CONCLUSIONS: Normal IOP nyctohemeral rhythm is lost in most patients with severe apnea. Nasal continuous positive airway pressure use restored a normal 24-hour IOP profile in most cases.
Jean-Louis Pépin; Christophe Chiquet; Renaud Tamisier; Patrick Lévy; Ahmed Almanjoumi; Jean-Paul Romanet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  128     ISSN:  1538-3601     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-12     Completed Date:  2010-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1257-63     Citation Subset:  AIM; IM    
Institut National de la Santé et de la Recherche Médicale (INSERM) Equipe Région Inserm 0017, Hypoxia and Physiopathology Laboratory, Joseph Fourier University, Grenoble, France.
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MeSH Terms
Blood Pressure / physiology
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm / physiology*
Continuous Positive Airway Pressure*
Intraocular Pressure / physiology*
Middle Aged
Sleep Apnea, Obstructive / physiopathology*,  therapy*

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