Document Detail

Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations.
MedLine Citation:
PMID:  7664859     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to assess the prevalence of throat and voice symptoms in asthma patients using pressurized aerosol, metered-dose, inhaled corticosteroid preparations. A questionnaire was administered to hospital out-patients in an asthma clinic and to a control group attending a diabetic clinic. Two hundred and fifty five consecutive out-patients using pressurized aerosol inhaled corticosteroids and 100 controls were surveyed. One hundred and forty seven (58%) patients taking inhaled steroids reported voice dysphonia or throat symptoms compared with 13% of control patients. Women admitted to symptoms more frequently than men. Throat symptoms were more prevalent in patients using higher doses of inhaled steroid. Aerosol inhaler-induced cough was reported by 87 (34%) patients. Local side-effects were equally prevalent both with beclomethasone dipropionate and budesonide aerosol inhalers. The use of a large volume spacing device with either steroid aerosol did not appear to protect against these symptoms. Local side-effects are common in asthmatics taking pressurized aerosol, metered-dose, inhaled steroids.
I J Williamson; S P Matusiewicz; P H Brown; A P Greening; G K Crompton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  8     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-10-06     Completed Date:  1995-10-06     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  590-2     Citation Subset:  IM    
Respiratory Unit, Western General Hospital, Edinburgh, Scotland.
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MeSH Terms
Anti-Inflammatory Agents / administration & dosage,  adverse effects*
Asthma / drug therapy*
Beclomethasone / administration & dosage,  adverse effects*
Case-Control Studies
Cough / chemically induced*,  epidemiology
Middle Aged
Nebulizers and Vaporizers
Outpatient Clinics, Hospital
Pregnenediones / administration & dosage,  adverse effects*
Voice Disorders / chemically induced*,  epidemiology
Reg. No./Substance:
0/Aerosols; 0/Anti-Inflammatory Agents; 0/Pregnenediones; 4419-39-0/Beclomethasone; 51333-22-3/Budesonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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