Document Detail

Frequency-varied versus unvaried pulsatile LH-RH substitution in hypothalamic amenorrhea.
MedLine Citation:
PMID:  6376195     Owner:  NLM     Status:  MEDLINE    
In 26 patients with hypothalamic amenorrhea cyclic ovarian function was reestablished by pulsatile LH-RH substitution. Two LH-RH regimens were tested. In group A (n = 13) LH-RH pulses (12 micrograms i.v.) were administered by means of a portable mini-pump (Auto-Syringe) at the unvaried frequency of one pulse every 96 min throughout the follicular phase. In group B (n = 13) LH-RH pulse intervals of 4 h (for 2 consecutive days), 3 h (for 1 day) and 96 min (for the rest of the follicular phase) were selected for initiation of follicle growth. After ovulation pump-assisted pulsatile LH-RH substitution was either maintained at the 96-min rhythm or replaced by LH-RH nasal-spray (200 micrograms/sniff) applied once every 4 h until the onset of menstruation or detection of pregnancy. While in group A patients changes in the pattern of luteal LH-RH support (pump-assisted versus nasal-spray assisted) resulted in rapid luteolysis, such effects did not occur in group B patients. It is suggested that LH-RH pulse frequency at the initial stage of follicular development is of importance for the quality of follicular development and thus luteal function. Both LH-RH regimens resulted in pregnancies (six times singletons and once twins). In the meantime, all children have been born and are healthy.
J P Hanker; E Nieschlag; H P Schneider
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  17     ISSN:  0301-2115     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  1984 May 
Date Detail:
Created Date:  1984-07-30     Completed Date:  1984-07-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  103-19     Citation Subset:  IM    
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MeSH Terms
Amenorrhea / drug therapy*,  physiopathology
Body Temperature / drug effects
Drug Administration Schedule
Estradiol / blood
Follicular Phase
Gonadotropin-Releasing Hormone / administration & dosage,  secretion,  therapeutic use*
Gonadotropins, Pituitary / blood
Hypothalamus / physiopathology
Infertility, Female / drug therapy
Ovulation / drug effects
Progesterone / blood
Reg. No./Substance:
0/Gonadotropins, Pituitary; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 57-83-0/Progesterone

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