| Frequency-varied versus unvaried pulsatile LH-RH substitution in hypothalamic amenorrhea. | |
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MedLine Citation:
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PMID: 6376195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 26 patients with hypothalamic amenorrhea cyclic ovarian function was reestablished by pulsatile LH-RH substitution. Two LH-RH regimens were tested. In group A (n = 13) LH-RH pulses (12 micrograms i.v.) were administered by means of a portable mini-pump (Auto-Syringe) at the unvaried frequency of one pulse every 96 min throughout the follicular phase. In group B (n = 13) LH-RH pulse intervals of 4 h (for 2 consecutive days), 3 h (for 1 day) and 96 min (for the rest of the follicular phase) were selected for initiation of follicle growth. After ovulation pump-assisted pulsatile LH-RH substitution was either maintained at the 96-min rhythm or replaced by LH-RH nasal-spray (200 micrograms/sniff) applied once every 4 h until the onset of menstruation or detection of pregnancy. While in group A patients changes in the pattern of luteal LH-RH support (pump-assisted versus nasal-spray assisted) resulted in rapid luteolysis, such effects did not occur in group B patients. It is suggested that LH-RH pulse frequency at the initial stage of follicular development is of importance for the quality of follicular development and thus luteal function. Both LH-RH regimens resulted in pregnancies (six times singletons and once twins). In the meantime, all children have been born and are healthy. |
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Authors:
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J P Hanker; E Nieschlag; H P Schneider |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of obstetrics, gynecology, and reproductive biology Volume: 17 ISSN: 0301-2115 ISO Abbreviation: Eur. J. Obstet. Gynecol. Reprod. Biol. Publication Date: 1984 May |
Date Detail:
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Created Date: 1984-07-30 Completed Date: 1984-07-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375672 Medline TA: Eur J Obstet Gynecol Reprod Biol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 103-19 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amenorrhea / drug therapy*, physiopathology Body Temperature / drug effects Drug Administration Schedule Estradiol / blood Female Follicular Phase Gonadotropin-Releasing Hormone / administration & dosage, secretion, therapeutic use* Gonadotropins, Pituitary / blood Humans Hypothalamus / physiopathology Infertility, Female / drug therapy Ovulation / drug effects Progesterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Gonadotropins, Pituitary; 33515-09-2/Gonadotropin-Releasing Hormone; 50-28-2/Estradiol; 57-83-0/Progesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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