Document Detail

Frequency of tuberous sclerosis in San-in district (Japan) and birth weight of patients with tuberous sclerosis.
MedLine Citation:
PMID:  7258549     Owner:  NLM     Status:  MEDLINE    
Fifty-two patients with tuberous sclerosis including 44 propositi were collected from 11 hospitals and 20 institutions in the San-in district. Of the 52 patients 44 were alive at the time of the study and the prevalence of tuberous sclerosis among the general population of the San-in district in October 1979 was estimated to be one in 31,000 (3.2 x 10(-5)), which was the highest value among the surveys in certain geographical areas. The frequency of tuberous sclerosis in live-births was estimated to be one in 24,000 (4.0 x 10(-5)). The frequency of the sporadic cases in live-births was one in 31,000 (3.2 X 10(-5) and the mutation rate was directly estimated to be 1.6 X 10(-5) per gene per generation. A difference between the parental age or birth order of the sporadic cases and those of controls was not detected. The mean birth weight for the tuberous sclerosis group was 2,834 g which was slightly less than the 2,985 g for their normal sibs. The frequency of low birth weight, less than 2,500 g, among the children with tuberous sclerosis was 30% (7/23), which was 4 times that in the general population (P less than 0.005). These facts suggest that the intrauterine growth is affected in a considerable number of the patients.
K Ohno; K Takeshita; M Arima
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain & development     Volume:  3     ISSN:  0387-7604     ISO Abbreviation:  Brain Dev.     Publication Date:  1981  
Date Detail:
Created Date:  1981-09-15     Completed Date:  1981-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909235     Medline TA:  Brain Dev     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
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MeSH Terms
Birth Order
Birth Weight*
Child, Preschool
Gene Frequency
Infant, Newborn
Maternal Age
Middle Aged
Tuberous Sclerosis / diagnosis,  epidemiology*,  genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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