Document Detail


Frequency transitions in odor-evoked neural oscillations.
MedLine Citation:
PMID:  20005825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In many species, sensory stimuli elicit the oscillatory synchronization of groups of neurons. What determines the properties of these oscillations? In the olfactory system of the moth, we found that odors elicited oscillatory synchronization through a neural mechanism like that described in locust and Drosophila. During responses to long odor pulses, oscillations suddenly slowed as net olfactory receptor neuron (ORN) output decreased; thus, stimulus intensity appeared to determine oscillation frequency. However, changing the concentration of the odor had little effect upon oscillatory frequency. Our recordings in vivo and computational models based on these results suggested that the main effect of increasing odor concentration was to recruit additional, less well-tuned ORNs whose firing rates were tightly constrained by adaptation and saturation. Thus, in the periphery, concentration is encoded mainly by the size of the responsive ORN population, and oscillation frequency is set by the adaptation and saturation of this response.
Authors:
Iori Ito; Maxim Bazhenov; Rose Chik-ying Ong; Baranidharan Raman; Mark Stopfer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuron     Volume:  64     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-01-05     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  692-706     Citation Subset:  IM    
Affiliation:
National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Biological / physiology
Analysis of Variance
Animals
Biological Clocks / physiology*
Brain Mapping
Dose-Response Relationship, Drug
Electrophysiology / methods
Evoked Potentials
Female
Male
Manduca
Membrane Potentials / physiology
Models, Neurological
Mushroom Bodies / cytology
Nerve Net / physiology
Neural Networks (Computer)
Odors*
Olfactory Pathways / cytology
Olfactory Receptor Neurons / physiology*
Smell / physiology*
Stimulation, Chemical
Grant Support
ID/Acronym/Agency:
Z99 HD999999/HD/NICHD NIH HHS; ZIA HD008760-07/HD/NICHD NIH HHS
Comments/Corrections

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