Document Detail

Frequency of thrombophilia in patients with adverse pregnancy outcome.
MedLine Citation:
PMID:  16045094     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the association between adverse pregnancy outcomes and thrombophilia. METHODS: This is a descriptive study, incorporating retrospective analysis of patients with recurrent pregnancy losses, intrauterine deaths, abruptio placenta and early onset pre eclampsia. Patients with adverse pregnancy outcomes in whom co-morbid factors were excluded underwent screening for both acquired and inherited thrombophilia. RESULTS: A total of 40 patients were screened for acquired and inherited thrombophilia with adverse pregnancy outcomes. Anticardiolipin antibodies were found positive in 55% of patients and 45% of patients were found deficient for natural anticoagulants protein C and S. Two patients were found positive for both acquired and inherited thrombophilia. CONCLUSION: Thrombophilia, both acquired and inherited are associated with adverse pregnancy outcomes. Patients in whom other co-morbid factors are excluded, should be offered screening for thrombophilia. Liaison between hematologist and obstetrician is the corner stone for success.
Nazli Hossain; Tahir Shamsi; Nargis Soomro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  JPMA. The Journal of the Pakistan Medical Association     Volume:  55     ISSN:  0030-9982     ISO Abbreviation:  J Pak Med Assoc     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-27     Completed Date:  2005-08-04     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  7501162     Medline TA:  J Pak Med Assoc     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, Unit 2, Civil Hospital, Karachi.
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MeSH Terms
Pregnancy Complications, Hematologic / epidemiology*
Pregnancy Outcome*
Retrospective Studies
Thrombophilia / epidemiology*

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