| Frequency-specific network connectivity increases underlie accurate spatiotemporal memory retrieval. | |
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MedLine Citation:
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PMID: 23354333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The medial temporal lobes, prefrontal cortex and parts of parietal cortex form the neural underpinnings of episodic memory, which includes remembering both where and when an event occurred. However, the manner in which these three regions interact during retrieval of spatial and temporal context remains untested. We employed simultaneous electrocorticographical recordings across multilobular regions in patients undergoing seizure monitoring while they retrieved spatial and temporal context associated with an episode, and we used phase synchronization as a measure of network connectivity. Successful memory retrieval was characterized by greater global connectivity compared with incorrect retrieval, with the medial temporal lobe acting as a hub for these interactions. Spatial versus temporal context retrieval resulted in prominent differences in both the spectral and temporal patterns of network interactions. These results emphasize dynamic network interactions as being central to episodic memory retrieval, providing insight into how multiple contexts underlying a single event can be recreated in the same network. |
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Authors:
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Andrew J Watrous; Nitin Tandon; Chris R Conner; Thomas Pieters; Arne D Ekstrom |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2013-01-27 |
Journal Detail:
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Title: Nature neuroscience Volume: 16 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2013 Mar |
Date Detail:
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Created Date: 2013-02-25 Completed Date: 2013-04-09 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 349-56 Citation Subset: IM |
Affiliation:
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Neuroscience Graduate Group, University of California, Davis, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / physiology*, physiopathology Brain Mapping Epilepsy / physiopathology Functional Neuroimaging Humans Memory / physiology* Mental Recall / physiology Nerve Net / physiology*, physiopathology Neuropsychological Tests Space Perception / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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R01NS076856/NS/NINDS NIH HHS |
| Comments/Corrections | |
Comment In:
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Nat Neurosci. 2013 Mar;16(3):257-8
[PMID:
23434977
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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