Document Detail

Frequency-specific effects of stimulation of the subthalamic area in treated Parkinson's disease patients.
MedLine Citation:
PMID:  19525877     Owner:  NLM     Status:  MEDLINE    
It has been hypothesized that too much synchronization in the beta band in basal ganglia-cortical circuits can contribute to bradykinesia and too little can contribute to hyperkinesia. The former has been supported by experiments in patients with Parkinson's disease and chronic implantation of the subthalamic area for deep brain stimulation. Stimulation at 20 Hz in this region slows voluntary tapping when performed in patients withdrawn from their usual antiparkinsonian medication. Here, we show the converse, that stimulation of the same region at 20 Hz in patients treated with levodopa decreases the interval between taps by 8.1+/-1.8% and makes tapping more regular. We suggest that this effect is mediated through an amelioration of levodopa-induced dyskinesias during stimulation.
Andrea A Kühn; Noa Fogelson; Patricia Dowsey Limousin; Marwan I Hariz; Andreas Kupsch; Peter Brown
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  20     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-30     Completed Date:  2009-10-12     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  975-8     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Antiparkinson Agents / therapeutic use
Deep Brain Stimulation / methods*
Electrodes, Implanted
Levodopa / therapeutic use
Middle Aged
Parkinson Disease / drug therapy,  therapy*
Psychomotor Performance / drug effects,  physiology*
Subthalamic Nucleus / drug effects,  physiopathology*
Grant Support
G0400617//Medical Research Council; //Medical Research Council
Reg. No./Substance:
0/Antiparkinson Agents; 46627O600J/Levodopa

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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