Document Detail


Frequency response characteristic of sympathetic mediated low-frequency blood pressure fluctuations in conscious rats.
MedLine Citation:
PMID:  16530023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A quantitative relationship between power densities of blood pressure (PBP) and sympathetic nerve activity (PSNA) in a low-frequency range (LF, 0.016-0.85 Hz), expressed as PSNA=PBPxax10bx(frequency) was proposed in pentobarbital-anesthetized rats. For evaluating the general applicability of this equation, the quantitative relationship of power density ratio Hf=PBP/PSNA across frequency was tested in a conscious state. Wistar rats were chronically instrumented with a femoral artery catheter and recording electrode around the renal sympathetic nerve. The blood pressure and renal sympathetic nerve activity were monitored both under pentobarbital anesthesia and in a conscious state. Linear regression analysis of the relationship between the frequency and logarithmic magnitude of the power density ratio in the LF range revealed excellent fit in both conditions (r=-0.96+/-0.01 and -0.93+/-0.01 for anesthetized and conscious rats, respectively). Comparing the regression lines, rats under pentobarbital anesthesia had significantly larger values for the y-intercept and slope compared to rats in a conscious state (y-intercepts: 0.80+/-0.09>0.53+/-0.08; slopes: -2.86+/-0.26>-1.62+/-0.21). Our results demonstrate that it is also feasible to use the weighted PBP in LF as a quantitative index of sympathetic variability in conscious rats, but the evaluation of possible complications controlling the regression parameters is called for.
Authors:
Ruei-Feng Chen; Wan-Ting Tseng; Wan-Ting Zeng; Chen-Tung Yen; Meng-Li Tsai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-03-09
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  128     ISSN:  1566-0702     ISO Abbreviation:  Auton Neurosci     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-20     Completed Date:  2006-09-08     Revised Date:  2009-08-12    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  48-52     Citation Subset:  IM    
Affiliation:
Institute of Zoology and Department of Life Science, National Taiwan University, Taipei, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / drug effects,  physiology
Adjuvants, Anesthesia / pharmacology
Animals
Arteries / innervation,  physiology*
Blood Pressure / drug effects*,  physiology*
Consciousness / physiology
Fourier Analysis
Male
Muscle, Smooth, Vascular / innervation,  physiology
Pentobarbital / pharmacology*
Rats
Rats, Wistar
Regression Analysis
Renal Artery / innervation,  physiology
Statistics as Topic / methods
Sympathetic Fibers, Postganglionic / drug effects*,  physiology*
Vasoconstriction / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Adjuvants, Anesthesia; 76-74-4/Pentobarbital
Comments/Corrections
Erratum In:
Auton Neurosci. 2007 Mar 30;132(1-2):107
Note: Zeng, Wan-Ting [corrected to Tseng, Wan-Ting]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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