Document Detail

Frequency of relapse after discontinuation of methotrexate therapy for clinical remission in juvenile rheumatoid arthritis.
MedLine Citation:
PMID:  7473486     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the outcome of children with juvenile rheumatoid arthritis (JRA) who discontinued taking methotrexate (MTX) therapy after the achievement of clinical remission. METHODS: We conducted a retrospective review of the clinical course of all consecutive patients with JRA treated with MTX at our department. RESULTS: Seventeen of the 30 patients who responded to treatment entered clinical remission 6 to 30 mo after beginning MTX therapy. All patients were discontinued from MTX within 2 to 5 mo. Five patients relapsed within 9 mo, whereas 12 patients had sustained remission for 12 mo or longer. Four of 5 children with extended pauciarticular JRA relapsed early after MTX discontinuation. These patients were less responsive to a further cycle of MTX, and 3 showed progression of radiographic joint lesions. CONCLUSION: These findings suggest that MTX should be continued in patients with extended pauciarticular JRA even after the achievement of clinical remission.
A Ravelli; S Viola; B Ramenghi; L Aramini; N Ruperto; A Martini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  22     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-12-12     Completed Date:  1995-12-12     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1574-6     Citation Subset:  IM    
Clinica Pediatrica dell'Universit?, Istituto di Ricovero e Cura a Carattere Scientifico S. Matteo, Pavia, Italy.
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MeSH Terms
Antirheumatic Agents / administration & dosage,  therapeutic use*
Arthritis, Juvenile Rheumatoid / drug therapy*
Child, Preschool
Methotrexate / administration & dosage,  therapeutic use*
Remission Induction
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Antirheumatic Agents; 59-05-2/Methotrexate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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