| Frequency of and reasons for medication non-fulfillment and non-persistence among American adults with chronic disease in 2008. | |
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MedLine Citation:
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PMID: 20860775 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Objective To identify self-reported reasons why adults with chronic disease do not fill a new prescription (medication non-fulfillment) and/or stop taking a medication without their physician telling them to do so (lack of medication persistence). Methods Participants were sampled in 2008 from a national, internet-based panel of American adults with chronic disease. A total of 19 830 respondents answered questions about medication non-fulfillment and medication non-persistence and reasons for non-fulfillment and non-persistence. Among persons self-identified as non-fulfillers and non-persisters, statistical analyses assessed the association between reported reasons for non-fulfillment and non-persistence and chronic disease. A subsample of respondents completed an additional survey which included multi-item scales assessing matched constructs of most of the reasons for non-fulfillment and non-persistence. The convergent validity of the self-reported reasons was assessed against the multi-item scales. Results The same four reasons were most commonly reported for both medication non-fulfillment and medication non-persistence: paying for the medication a financial hardship (56 and 43%, respectively); fear or experience of side effects (46 and 35%, respectively); generic concerns about medications (32 and 23%, respectively); and lack of perceived need for the medication (25 and 23%, respectively). The frequency with which the reasons were reported varied somewhat by chronic disease. The convergent validity of most of the self-reported reasons was confirmed against multi-item scales measuring matched constructs. Conclusions The same top reasons for medication non-fulfillment and non-adherence were observed in a large internet-based sample of American adults with chronic disease. Future efforts to improve medication adherence should address patients' medication concerns, perceived need for medications, and perceived medication affordability. |
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Authors:
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Colleen A McHorney; Charles V Spain |
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Publication Detail:
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Type: Journal Article Date: 2010-09-23 |
Journal Detail:
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Title: Health expectations : an international journal of public participation in health care and health policy Volume: 14 ISSN: 1369-7625 ISO Abbreviation: Health Expect Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-08-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815926 Medline TA: Health Expect Country: England |
Other Details:
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Languages: eng Pagination: 307-20 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Senior Director Epidemiologist, US Outcomes Research, Merck & Co., Inc., North Wales, PA, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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