| Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis. | |
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MedLine Citation:
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PMID: 20850793 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Antibodies to aquaporin-4 (AQP4-Ab) are found in 60-80% of patients with neuromyelitis optica (NMO), a severely disabling inflammatory CNS disorder of putative autoimmune aetiology, which predominantly affects the optic nerves and spinal cord. OBJECTIVE: To assess the frequency of AQP4-Ab in patients with optic neuritis (ON), and to investigate the prognostic implications of AQP4-Ab seropositivity in such patients. PATIENTS AND METHODS: AQP4-Ab serum levels were determined in 224 individuals from Austria, Denmark, France, Germany, Italy, and Turkey using a newly developed fluorescence immunoprecipitation assay employing recombinant human AQP4. RESULTS: AQP4-Ab were detectable in 8/139 (5.8%) patients with acute monosymptomatic optic neuritis (AMON) and in 10/17 (58.8%) patients with established NMO and a last relapse of acute ON (NMO/ON), but not in 32 patients with multiple sclerosis or in 36 healthy controls. At last examination, 4/8 (50%) seropositive AMON patients had met the criteria for NMO but 0/128 seronegative AMON patients. Disease severity differed significantly between seropositive and seronegative AMON. Complete bilateral or unilateral blindness occurred in six AQP4-Ab positive patients, but only in one AQP4-Ab negative patient. AQP4-Ab levels did not vary between seropositive AMON and NMO/ON and did not correlate with disease severity. Female gender, a relapsing course, and concomitant autoimmunity were associated with AQP4-Ab seropositive status and risk of developing NMO. CONCLUSION: AQP4-Ab is relatively rare among patients with AMON, but if present it predicts a high rate of conversion to NMO within one year. |
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Authors:
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Sven Jarius; Jette Frederikson; Patrick Waters; Friedemann Paul; Gulsen Akman-Demir; Romain Marignier; Diego Franciotta; Klemens Ruprecht; Bettina Kuenz; Paulus Rommer; Wolfgang Kristoferitsch; Brigitte Wildemann; Angela Vincent |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-18 |
Journal Detail:
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Title: Journal of the neurological sciences Volume: 298 ISSN: 1878-5883 ISO Abbreviation: J. Neurol. Sci. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-18 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375403 Medline TA: J Neurol Sci Country: Netherlands |
Other Details:
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Languages: eng Pagination: 158-62 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Antibodies / blood* Aquaporin 4 / immunology* Disease Progression Female Fluorescent Antibody Technique Humans Immunoprecipitation Male Middle Aged Neuromyelitis Optica / epidemiology, pathology Optic Neuritis / epidemiology, immunology*, pathology Prognosis Recurrence Sex Factors Treatment Outcome Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 0/Aquaporin 4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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