Document Detail


Frequency and prognostic impact of antibodies to aquaporin-4 in patients with optic neuritis.
MedLine Citation:
PMID:  20850793     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Antibodies to aquaporin-4 (AQP4-Ab) are found in 60-80% of patients with neuromyelitis optica (NMO), a severely disabling inflammatory CNS disorder of putative autoimmune aetiology, which predominantly affects the optic nerves and spinal cord.
OBJECTIVE: To assess the frequency of AQP4-Ab in patients with optic neuritis (ON), and to investigate the prognostic implications of AQP4-Ab seropositivity in such patients.
PATIENTS AND METHODS: AQP4-Ab serum levels were determined in 224 individuals from Austria, Denmark, France, Germany, Italy, and Turkey using a newly developed fluorescence immunoprecipitation assay employing recombinant human AQP4.
RESULTS: AQP4-Ab were detectable in 8/139 (5.8%) patients with acute monosymptomatic optic neuritis (AMON) and in 10/17 (58.8%) patients with established NMO and a last relapse of acute ON (NMO/ON), but not in 32 patients with multiple sclerosis or in 36 healthy controls. At last examination, 4/8 (50%) seropositive AMON patients had met the criteria for NMO but 0/128 seronegative AMON patients. Disease severity differed significantly between seropositive and seronegative AMON. Complete bilateral or unilateral blindness occurred in six AQP4-Ab positive patients, but only in one AQP4-Ab negative patient. AQP4-Ab levels did not vary between seropositive AMON and NMO/ON and did not correlate with disease severity. Female gender, a relapsing course, and concomitant autoimmunity were associated with AQP4-Ab seropositive status and risk of developing NMO.
CONCLUSION: AQP4-Ab is relatively rare among patients with AMON, but if present it predicts a high rate of conversion to NMO within one year.
Authors:
Sven Jarius; Jette Frederikson; Patrick Waters; Friedemann Paul; Gulsen Akman-Demir; Romain Marignier; Diego Franciotta; Klemens Ruprecht; Bettina Kuenz; Paulus Rommer; Wolfgang Kristoferitsch; Brigitte Wildemann; Angela Vincent
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-18
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  298     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-18     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  158-62     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Antibodies / blood*
Aquaporin 4 / immunology*
Disease Progression
Female
Fluorescent Antibody Technique
Humans
Immunoprecipitation
Male
Middle Aged
Neuromyelitis Optica / epidemiology,  pathology
Optic Neuritis / epidemiology,  immunology*,  pathology
Prognosis
Recurrence
Sex Factors
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/Antibodies; 0/Aquaporin 4

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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