Document Detail


Frequency and predictors of renal artery stenosis in patients with coronary artery disease.
MedLine Citation:
PMID:  19159851     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Renal artery stenosis (RAS) remains underdiagnosed because of nonspecific clinical manifestations, including in patients with coronary artery disease (CAD). AIMS: To estimate the prevalence and identify predictors of RAS in patients with CAD undergoing coronary angiography. SETTING: University-based medical centre. METHODS: We enrolled 650 consecutive patients (mean age=67+/-10 years, 80% men) with confirmed CAD. All patients underwent selective renal arteriography in the same procedure. We estimated the prevalence of RAS, defined as a >50% lesion. Multiple variable analysis of factors associated with presence of RAS was carried out using a logistic regression model. Variables that emerged as predictors by single-variable analysis were included in the model, along with variables that were tentatively associated with RAS, based on a literature review. RESULTS: RAS was detected in 94 patients (14.5%, 95% CI: 11.8-17.2%), including 20 (3.1%) with bilateral lesions. By single-variable analysis and presence and number of coronary artery stenoses (P<.001), hypertension (P=.001), and creatinine clearance <90 ml/min (P<.001) were associated with an increased risk of RAS. By multiple variable analysis, male sex (P<.05), presence and number of coronary artery lesions (P<.01), hypertension (P=.001), and renal insufficiency (P<.001) predicted the presence of RAS. CONCLUSIONS: The main clinical predictors of RAS in patients with CAD were hypertension, renal insufficiency, and multivessel CAD. These observations might help defining a high-risk subgroup of patients in need of meticulous investigations of both CAD and RAS.
Authors:
Romain Ollivier; Dominique Boulmier; David Veillard; Guillaume Leurent; Stéphane Mock; Marc Bedossa; Hervé Le Breton
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular revascularization medicine : including molecular interventions     Volume:  10     ISSN:  1878-0938     ISO Abbreviation:  -     Publication Date:    2009 Jan-Mar
Date Detail:
Created Date:  2009-01-22     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101238551     Medline TA:  Cardiovasc Revasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-9     Citation Subset:  IM    
Affiliation:
INSERM, U642, Rennes, F-35000, France. romain.ollivier@chu-rennes.fr
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Coronary Angiography*
Coronary Stenosis / complications,  epidemiology,  radiography*
Creatinine / blood
Female
Humans
Hypertension / complications
Logistic Models
Male
Middle Aged
Prevalence
Prospective Studies
Renal Artery Obstruction / epidemiology,  etiology,  radiography*
Renal Insufficiency / complications
Risk Assessment
Risk Factors
Severity of Illness Index
Sex Factors
Chemical
Reg. No./Substance:
60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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