| Frequency and predictors of renal artery stenosis in patients with coronary artery disease. | |
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MedLine Citation:
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PMID: 19159851 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Renal artery stenosis (RAS) remains underdiagnosed because of nonspecific clinical manifestations, including in patients with coronary artery disease (CAD). AIMS: To estimate the prevalence and identify predictors of RAS in patients with CAD undergoing coronary angiography. SETTING: University-based medical centre. METHODS: We enrolled 650 consecutive patients (mean age=67+/-10 years, 80% men) with confirmed CAD. All patients underwent selective renal arteriography in the same procedure. We estimated the prevalence of RAS, defined as a >50% lesion. Multiple variable analysis of factors associated with presence of RAS was carried out using a logistic regression model. Variables that emerged as predictors by single-variable analysis were included in the model, along with variables that were tentatively associated with RAS, based on a literature review. RESULTS: RAS was detected in 94 patients (14.5%, 95% CI: 11.8-17.2%), including 20 (3.1%) with bilateral lesions. By single-variable analysis and presence and number of coronary artery stenoses (P<.001), hypertension (P=.001), and creatinine clearance <90 ml/min (P<.001) were associated with an increased risk of RAS. By multiple variable analysis, male sex (P<.05), presence and number of coronary artery lesions (P<.01), hypertension (P=.001), and renal insufficiency (P<.001) predicted the presence of RAS. CONCLUSIONS: The main clinical predictors of RAS in patients with CAD were hypertension, renal insufficiency, and multivessel CAD. These observations might help defining a high-risk subgroup of patients in need of meticulous investigations of both CAD and RAS. |
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Authors:
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Romain Ollivier; Dominique Boulmier; David Veillard; Guillaume Leurent; Stéphane Mock; Marc Bedossa; Hervé Le Breton |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cardiovascular revascularization medicine : including molecular interventions Volume: 10 ISSN: 1878-0938 ISO Abbreviation: - Publication Date: 2009 Jan-Mar |
Date Detail:
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Created Date: 2009-01-22 Completed Date: 2009-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101238551 Medline TA: Cardiovasc Revasc Med Country: United States |
Other Details:
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Languages: eng Pagination: 23-9 Citation Subset: IM |
Affiliation:
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INSERM, U642, Rennes, F-35000, France. romain.ollivier@chu-rennes.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Coronary Angiography* Coronary Stenosis / complications, epidemiology, radiography* Creatinine / blood Female Humans Hypertension / complications Logistic Models Male Middle Aged Prevalence Prospective Studies Renal Artery Obstruction / epidemiology, etiology, radiography* Renal Insufficiency / complications Risk Assessment Risk Factors Severity of Illness Index Sex Factors |
| Chemical | |
Reg. No./Substance:
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60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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