| Frequency and outcome of cervical cancer prevention failures in the United States. | |
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MedLine Citation:
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PMID: 17951205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We measured the frequency and outcome of cervical cancer prevention failures that occurred in the Papanicolaou (Pap) and colposcopy testing phases involving 1,646,580 Pap tests in 4 American hospital systems between January 1, 1998, and December 31, 2004. We defined a screening failure as a 2-step or greater discordant Pap test result and follow-up biopsy diagnosis. A total of 5,278 failures were detected (0.321% of all Pap tests); 48% and 52% of failures occurred in the Pap test and colposcopy phases, respectively. Missed squamous cancers (1 in 187,786 Pap tests), glandular cancers (1 in 19,426 Pap tests), and high-grade lesions (1 in 6,870 Pap tests) constituted 4.1% of all failures. Unnecessary repeated tests or diagnostic delays occurred in 70.8% and 63.9% of failures involving high- and low-grade lesions, respectively. We conclude that cervical cancer prevention practices are remarkably successful in preventing squamous cancers, although a high frequency of failures results in low-impact negative outcomes. |
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Authors:
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Stephen S Raab; Dana Marie Grzybicki; Richard J Zarbo; Chris Jensen; Stanley J Geyer; Janine E Janosky; Frederick A Meier; Colleen M Vrbin; Gloria Carter; Kim R Geisinger |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of clinical pathology Volume: 128 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-22 Completed Date: 2007-11-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 817-24 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, and Western Pennsylvania Hospital 15232, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Colposcopy
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standards,
statistics & numerical data* Diagnostic Errors / standards, statistics & numerical data* Female Humans Mass Screening / standards, statistics & numerical data* Neoplasm Staging Patient Care Management / statistics & numerical data Predictive Value of Tests* Reproducibility of Results Uterine Cervical Neoplasms / diagnosis*, prevention & control Vaginal Smears / standards, statistics & numerical data* |
| Grant Support | |
ID/Acronym/Agency:
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HJS13321-01//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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