| Frequency and nature of drug-drug interactions in a Swiss primary and secondary acute care hospital. | |
| | |
MedLine Citation:
|
PMID: 22327947 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
QUESTIONS UNDER STUDY: Drug-drug interactions (DDI) are considered a risk factor in medication safety and computerised alerting tools are increasingly promoted and implemented in order to detect and minimise DDI. As only little is known about the frequency and nature of DDI in hospitalised patients in Switzerland as well as about the usefulness of current alerting systems, this analysis based on a computerised medication record in a typical regional hospital setting was performed. METHODS: All inpatients with at least one drug prescription between 2006 and 2010 were included. A total of 1,654,987 prescriptions were analysed with regard to the maximal seriousness level of DDI between each added prescription versus the existing prescription and with regard to all underlying DDI. RESULTS: On average, each inpatient received 16 different drugs including on-demand prescriptions and encountered 5 DDI. A total of 27% of all prescriptions caused DDI. Within the last 12 months, 5% of all DDI were classified in category 1 (contraindicated), 3% in category 2, 53% in category 3, 8% in category 4 and 31% in category 5. The vast majority of DDI were caused by a very limited number of drugs. DISCUSSION: Drug-drug interactions were very frequent and were very stable over the years studied, involving on average 27% of all prescriptions and 44% in internal medicine. Only a very limited amount of drugs were responsible for the vast majority of DDI, especially when the most severe categories of DDI were considered. Most of the severe DDI alerts could be automatically handled, if for example laboratory values could be taken into account. The DDI database should ideally be supplemented by information enabling more sophisticated computerised support in order to deliver more reasonable results from DDI checks. |
| | |
Authors:
|
M Oertle |
Related Documents
:
|
22420577 - Pharmacokinetics and pharmacodynamics of intraperitoneal cancer chemotherapeutics. 22479767 - Would decriminalising drugs improve care? 22405967 - Aminoalkyl methacrylate copolymers for improving the solubility of tacrolimus. i: evalu... 3511657 - Diuretic therapeutics in the pediatric patient. 17872777 - Teratogenicity of lamotrigine. 9671567 - Serum transaminase elevations as indicators of hepatic injury following the administrat... |
Publication Detail:
|
Type: Journal Article Date: 2012-02-10 |
Journal Detail:
|
Title: Swiss medical weekly Volume: 142 ISSN: 1424-3997 ISO Abbreviation: Swiss Med Wkly Publication Date: 2012 |
Date Detail:
|
Created Date: 2012-02-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100970884 Medline TA: Swiss Med Wkly Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 0 Citation Subset: IM |
Affiliation:
|
Spital Thun-Simmental AG, Department for Internal Medicine and Group of Medical Informatics, CH-Thun, Switzerland; Marc.oertle@spitalstsag.ch. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dual delivery for stem cell differentiation using dexamethasone and bFGF in/on polymeric microsphere...
Next Document: New concepts in neonatal resuscitation.