| Frequency-modulated electromagnetic neural stimulation enhances cutaneous microvascular flow in patients with diabetic neuropathy. | |
| | |
MedLine Citation:
|
PMID: 18403219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: The aim of this study was to investigate the effects of frequency modulated electromagnetic neural stimulation (FREMS), a recently developed safe and effective treatment of painful diabetic neuropathy, on cutaneous microvascular function. METHODS: Thirty-one patients with painful neuropathy were enrolled in a randomised, double-blind, crossover FREMS vs. placebo study; each received two series of 10 treatments of either FREMS or placebo in random sequence within no more than 3 weeks. Patients were studied at baseline, end of FREMS and placebo series, and after 4 months of follow-up. Cutaneous blood flow was measured by laser doppler flowmetry and partial tissue tension of oxygen (TcPO2) and carbonic anhydride (TcPCO2) by oxymetry at the lower extremities in basal resting conditions and as incremental response after thermal stimulation. RESULTS: Crossover analysis showed no consistent differences between FREMS and placebo. After 4-month follow-up, a 52% increase of cutaneous blood flow was observed in resting conditions (P=.0086 vs. baseline), while no differences were observed as incremental flow after warming; compared with baseline, no significant differences were observed for TcPO2 and TcPCO2, both in resting conditions and as incremental response to warm. CONCLUSION: These results indicate that 10 treatments with FREMS may induce an enhancement of microvascular blood flow measurable at 4 months of follow-up. The findings of this study will need to be confirmed in a larger, adequately powered study (ClinicalTrial.gov Id: NCT00337324). |
| | |
Authors:
|
Morena Conti; Elena Peretti; Giuliana Cazzetta; Gabriella Galimberti; Cristiana Vermigli; Roberto Pola; Luciano Scionti; Emanuele Bosi |
Related Documents
:
|
8678359 - Dynamic model of oxygen transport for transcutaneous po2 analysis. 76169 - Continuous monitoring of mixed venous oxygen tension (pvo2) in cardiorespiratory disord... 939109 - The validity of the transcutaneous oxygen tension method in adults. 15529 - Effect of external factors on phototaxis of chlamydomonas reinhardtii. ii. charbon diox... 8342929 - Tissue oxygenation and blood flow on specialized and conventional hospital beds. 971549 - Effects of quinidine on blood flow rate and developed tension in blood-perfused canine ... 1163989 - Cerebral blood flow in patients undergoing microanastomosis for modification for preven... 12175979 - Near-infrared spectrometric determination of blood ph. 11697429 - Acute postnatal increase of extracellular antioxidant defence of neonates: the role of ... |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-04-10 |
Journal Detail:
|
Title: Journal of diabetes and its complications Volume: 23 ISSN: 1873-460X ISO Abbreviation: J. Diabetes Complicat. Publication Date: 2009 Jan-Feb |
Date Detail:
|
Created Date: 2008-12-01 Completed Date: 2009-02-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9204583 Medline TA: J Diabetes Complications Country: United States |
Other Details:
|
Languages: eng Pagination: 46-8 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Via Olgettina, 60, 20132 Milan, Italy. |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ClinicalTrials.gov/NCT00337324 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Diabetic Neuropathies
/
therapy* Electromagnetic Fields* Female Humans Magnetic Field Therapy* Male Microcirculation / radiation effects* Middle Aged Nervous System / radiation effects* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in p...
Next Document: Predictive factors for postoperative outcome in temporal lobe epilepsy according to two different cl...