Document Detail

Frequency, management, and outcome of extravasation of nonionic iodinated contrast medium in 69,657 intravenous injections.
MedLine Citation:
PMID:  17392249     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To determine retrospectively the frequency, management, and outcomes of extravasations of intravenously injected nonionic iodinated contrast medium. MATERIALS AND METHODS: Institutional review board approval was obtained, and the requirement for informed consent was waived. The study was HIPAA compliant. For 69,657 intravenous injections of nonionic iodinated contrast medium for computed tomographic examinations between January 1, 2000, and March 31, 2005, the incident reports, radiology reports, and medical records of patients in whom contrast medium extravasations occurred were reviewed. Data collected included patient age, catheter gauge, injection site, volume extravasated, patient symptoms, severity of injury, treatment, whether or not the plastic surgery service was consulted and any additional treatment that service instituted, and patient outcome. RESULTS: Extravasations occurred in 475 (0.7%) of 69 657 patients, and follow-up information was available for 442 adults (280 women, 162 men; mean age, 57 years) and 17 children (nine girls, eight boys; mean age, 6 years). Extravasated volumes ranged from 3 to 150 mL. Symptoms usually consisted of swelling and/or pain. The plastic surgery service was consulted for 38 adults and six children and provided additional treatment in eight patients (seven adults, one child). Among adults, 432 had minimal or no adverse effects, nine had moderate adverse effects, and one had a severe complication (75 mL of contrast material extravasated into the hand, causing compartment syndrome). Only one moderate or severe complication in an adult resulted from an extravasation of less than 50 mL. Fifteen children had minimal or no adverse effects, one had moderate adverse effects, and one had a severe complication (18 mL of contrast material extravasated into the arm, causing brachial plexopathy). CONCLUSION: Extravasation of nonionic iodinated contrast medium results only rarely in moderate or severe adverse effects, and these usually occur only when large volumes of contrast medium are involved.
Carolyn L Wang; Richard H Cohan; James H Ellis; Saroja Adusumilli; N Reed Dunnick
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiology     Volume:  243     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-29     Completed Date:  2007-05-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  80-7     Citation Subset:  AIM; IM    
Department of Radiology, University of Michigan Health System, Ann Arbor, MI 48109-0030, USA.
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MeSH Terms
Aged, 80 and over
Child, Preschool
Contrast Media / adverse effects*
Extravasation of Diagnostic and Therapeutic Materials* / epidemiology,  therapy
Infant, Newborn
Injections, Intravenous / adverse effects
Middle Aged
Retrospective Studies
Surgery, Plastic
Tomography, X-Ray Computed / adverse effects*
Reg. No./Substance:
0/Contrast Media; 7553-56-2/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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