Document Detail

Frequency and location of microbleeds in patients with primary intracerebral hemorrhage.
MedLine Citation:
PMID:  11062292     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: MRI is known to detect clinically silent microbleeds (MBs) in patients with primary intracerebral hemorrhage (pICH), but the frequency and diagnostic and clinical significance of this finding are still debated. Therefore, we investigated a consecutive series of pICH patients and analyzed the patterns of MB distribution in the context of clinical variables and location of the symptomatic hematoma. METHODS: The study population consisted of 109 patients with pICH. There were 59 women and 50 men aged 22 to 91 years (mean 64.6 years). MRI was obtained on a 1.5-T system with use of a gradient-echo T2*-weighted sequence. A cohort of 280 community-dwelling asymptomatic elderly individuals who underwent the same imaging protocol served for comparison. RESULTS: MBs were seen in 59 (54%) patients and ranged in number from 1 to 90 lesions (mean 14, median 6). In the majority of patients, MBs were located simultaneously in various parts of the brain, with a preference for cortical-subcortical regions (39%) and the basal ganglia/thalami (38%). There was some tendency toward a regional association between MB location and the site of the symptomatic hematoma, but we could not discern specific patterns of MB distribution. Logistic regression analysis identified MBs, periventricular hyperintensity grades, and lacunes but not risk factors as independent variables contributing to a correct classification of pICH and control individuals. CONCLUSIONS: MBs can be detected in more than half of the patients with pICH and appear to be quite general markers of various types of bleeding-prone microangiopathy.
G Roob; A Lechner; R Schmidt; E Flooh; H P Hartung; F Fazekas
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  31     ISSN:  1524-4628     ISO Abbreviation:  Stroke     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-08     Completed Date:  2000-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2665-9     Citation Subset:  IM    
Department of Neurology, Karl-Franzens University, Graz, Austria.
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MeSH Terms
Aged, 80 and over
Basal Ganglia / pathology
Brain / pathology*
Cerebral Cortex / pathology
Cerebral Hemorrhage / diagnosis*,  pathology*
Hematoma / diagnosis*,  pathology*
Magnetic Resonance Imaging / statistics & numerical data*
Middle Aged
Thalamus / pathology

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